Table 3 Tumor response by RET fusion status

Any first-line therapy, unadjusted

n (%)^a

n (%)^a

 Complete response (CR)

1 (3.7)

112 (4.7)

0.17

 Partial response (PR)

20 (74.1)

1284 (53.9)

 Stable disease (SD)

2 (7.4)

530 (22.3)

 Progressive Disease (PD)

4 (14.8)

455 (19.1)

 Missing/unknown

19

3380

First-line pembro + PC (KN-189 regimen), unadjusted

N = 9

N = 665

 CR

1 (12.5)

15 (3.4)

0.15

 PR

5 (62.5)

249 (57.1)

 SD

0 (0.0)

100 (22.9)

 PD

2 (25.0)

72 (16.5)

 Missing/unknown

1

229

Any second-line therapy, unadjusted

N = 23

N = 3173

 CR

0 (0.0)

47 (2.9)

0.93

 PR

6 (42.9)

564 (35.1)

 SD

4 (28.6)

478 (29.7)

 PD

4 (28.6)

519 (32.3)

 Missing/unknown

9

1565

Objective response rate (ORR)

p-value

 First line, unadjusted, n = 2408

0.05

 First-line pembro +PC , unadjusted, n = 444

0.49

 First line, adjusted^b, n = 2408

0.09

 First line pembro + PC, adjusted^b, n = 444

0.61

 Second line, unadjusted, n = 1622

0.78

 Second line, adjusted^b, n = 1622

0.36