Characteristics | Overall N = 5807 | RET+ N = 46 | RET- N = 5761 | RET+ vs RET- P value* |
---|---|---|---|---|
Body weight (kg) | ||||
 Mean (Sd) | 75.7 (18.8) | 74.9 (16.2) | 75.7 (18.8) | 0.81 |
 Median (IQR) | 73.7 (62.1, 86.4) | 70.1 (62.8, 86.4) | 73.8 (62.1, 86.4) |  |
BMI category, n (%) | ||||
 Underweight | 302 (5.4) | 2 (4.7) | 300 (5.4) | 0.82 |
 Normal | 2203 (39.1) | 20 (46.5) | 2183 (39.0) |  |
 Overweight | 1843 (32.7) | 13 (30.2) | 1830 (32.7) |  |
 Obese | 1289 (22.9) | 8 (18.6) | 1281 (22.9) |  |
 Missing/Unknown | 170 | 3 | 167 |  |
Stage at initial diagnosis, n (%) | ||||
 Stage I | 486 (8.5) | 3 (6.5) | 483 (8.6) | 0.34 |
 Stage II | 335 (5.9) | 0 (0.0) | 335 (5.9) |  |
 Stage III | 1154 (20.3) | 9 (19.6) | 1145 (20.3) |  |
 Stage IV | 3714 (65.3) | 34 (73.9) | 3680 (65.2) |  |
 Missing/Unknown | 118 | 0 | 118 |  |
Histology, n (%) | ||||
 Non-squamous | 4437 (79.6) | 45 (100.0) | 4392 (79.4) | < 0.0001 |
 Squamous | 1138 (20.4) | 0 (0.0) | 1138 (20.6) |  |
 Missing/Unknown | 232 | 1 | 231 |  |
Smoking status, n (%) | ||||
 Smoking history | 4720 (81.5) | 17 (37.0) | 4703 (81.9) | < 0.0001 |
 No smoking history | 1071 (18.5) | 29 (63.0) | 1042 (18.1) |  |
 Missing/Unknown | 16 | 0 | 16 |  |
ECOG performance status, n (%) | ||||
 0 | 1438 (33.8) | 19 (61.3) | 1419 (33.6) | 0.02 |
 1 | 2088 (49.1) | 9 (29.0) | 2079 (49.2) |  |
 2 | 595 (14.0) | 2 (6.5) | 593 (14.0) |  |
 3+ | 136 (3.2) | 1 (3.2) | 135 (3.2) |  |
 Missing/Unknown | 1550 | 15 | 1535 |  |
RET fusion partner | ||||
 KIF5B | – | 29 (63.0) | – | – |
 CCDC6 | – | 11 (23.9) | – |  |
 NCOA4 | – | 3 (6.5) | – |  |
 Otherd | – | 3 (6.5) | – |  |
EGFR positive, n (%) | ||||
 Yes | 447 (18.8) | 3 (8.6) | 444 (18.9) | 0.19 |
 No | 1936 (81.2) | 32 (91.4) | 1904 (81.1) |  |
 Missing/Unknown | 3424 | 11 | 3413 |  |
ALK positive, n (%) | ||||
 Yes | 80 (3.7) | 0 (0.0) | 80 (3.8) | 0.64 |
 No | 2086 (96.3) | 34 (100.0) | 2052 (96.3) |  |
 Missing/Unknown | 3641 | 12 | 3629 |  |
KRAS positive, n (%) | ||||
 Yes | 233 (24.6) | 0 (0.0) | 233 (25.0) | 0.05 |
 No | 714 (75.4) | 13 (100.0) | 701 (75.1) |  |
 Missing/Unknown | 4860 | 33 | 4827 |  |
ROS1 positive, n (%) | ||||
 Yes | 16 (1.2) | 0 (0.00) | 16 (1.2) | 1.0 |
 No | 1310 (98.8) | 19 (100.0) | 1291 (98.8) |  |
 Missing/Unknown | 4481 | 27 | 4454 |  |
BRAF positive, n (%) | ||||
 Yes | 42 (4.9) | 0 (0.0) | 42 (4.9) | 1.0 |
 No | 820 (95.1) | 7 (100.0) | 813 (95.1) |  |
 Missing/Unknown | 4945 | 39 | 4906 |  |
MSI status, n (%) | ||||
 MSI high | 7 (0.2) | 0 (0.0) | 7 (0.3) | 1.0 |
 MSI stable | 2849 (99.3) | 22 (100.0) | 2827 (99.3) |  |
 MSI intermediate | 13 (0.5) | 0 (0.0) | 13 (0.5) |  |
 Missing/Unknown | 2938 | 24 | 2914 |  |
PD-L1 expressiona, n (%) | ||||
 Positive (≥ 1%) | 1206 (47.4) | 15 (68.2) | 1191 (47.2) | 0.06 |
 Negative | 1337 (52.6) | 7 (31.8) | 1330 (52.8) |  |
 Missing/Unknown | 3264 | 24 | 3240 |  |
FMI PD-L1 expressionb, n (%) | ||||
 High Positive (≥50%) | 390 (31.2) | 2 (28.6) | 388 (31.2) | 0.21 |
 Low Positive (1–49%) | 353 (28.2) | 4 (57.1) | 349 (28.1) |  |
 Negative | 507 (40.6) | 1 (14.3) | 506 (40.7) |  |
 Missing/Unknown | 4557 | 39 | 4518 |  |
Time from metastatic diagnosis to FMI testc, days | ||||
 Mean (Sd) | 86.7 (427.1) | 135.9 (480.4) | 86.3 (426.6) | 0.43 |
 Median (IQR) | 0 (0.0, 49.0) | 1.5 (0.0, 441.0) | 0 (0.0, 49.0) |  |
Adrenal metastases, n (%) | ||||
 Yes | 657 (11.3) | 3 (6.5) | 654 (11.4) | 0.48 |
 Not reported | 5150 (88.7) | 43 (93.5) | 5107 (88.7) | . |
Bone metastases, n (%) | ||||
 Yes | 2018 (34.8) | 21 (45.7) | 1997 (34.7) | 0.12 |
 Not reported | 3789 (65.3) | 25 (54.4) | 3764 (65.3) |  |
Brain metastases, n (%) | ||||
 Yes | 1156 (19.9) | 9 (19.6) | 1147 (19.9) | 1.0 |
 Not reported | 4651 (80.1) | 37 (80.4) | 4614 (80.1) |  |
Distant lymph node metastases, n (%) | ||||
 Yes | 808 (13.9) | 7 (15.2) | 801 (13.9) | 0.83 |
 Not reported | 4999 (86.1) | 39 (84.8) | 4960 (86.1) |  |
Liver metastases, n (%) | ||||
 Yes | 697 (12.0) | 13 (28.3) | 684 (11.9) | 0.0007 |
 Not reported | 5110 (88.0) | 33 (71.7) | 5077 (88.1) |  |
Other metastases, n (%) | ||||
 Yes | 4176 (71.9) | 27 (58.7) | 4149 (72.0) | 0.05 |
 Not reported | 1631 (28.1) | 19 (41.3) | 1612 (28.0) |  |