|
A. Clinical trial dose toxicity curves
|
|
Dose escalation method
|
True dose toxicity curve
|
|
AZD3514
|
AZD1208
|
AZD1480
|
AZD4877
|
|
3 + 3
|
64.9
|
50.5
|
45.5
|
100.0
|
|
Extended CRM
|
Conservative
|
71.7
|
66.8
|
60.9
|
100.0
|
|
Aggressive
|
34.8
|
88.3
|
51.0
|
100.0
|
|
Step-up
|
57.6
|
88.9
|
60.1
|
100.0
|
|
Dose-Linear
|
36.4
|
98.5
|
60.4
|
100.0
|
|
Sigmoidal
|
71.4
|
66.8
|
68.4
|
100.0
|
|
O’Quigley
|
56.5
|
78.2
|
59.8
|
100.0
|
|
B. Theoretical dose toxicity curves
|
|
Dose escalation method
|
True dose toxicity curve
|
|
Conservative
|
Step-up
|
Dose-linear
|
Sigmoidal
|
|
3 + 3
|
33.1
|
22.7
|
36.8
|
46.6
|
|
Extended CRM
|
Conservative
|
63.4
|
43.9
|
53.9
|
50.3
|
|
Aggressive
|
44.6
|
30.8
|
48.2
|
33.9
|
|
Step-up
|
44.5
|
29.8
|
64.2
|
32.6
|
|
Dose-Linear
|
39.7
|
23.6
|
62.7
|
22.8
|
|
Sigmoidal
|
51.7
|
33.0
|
67.8
|
33.2
|
|
O’Quigley
|
40.4
|
27.3
|
65.9
|
28.9
|
- The method which correctly identified the MTD of a true dose toxicity curve in the greatest percentage of simulations is italicised and emboldened. The method which correctly identified the MTD of a true dose toxicity curve in the lowest percentage of simulations is italicised and underlined
