Table 2 Proportion of simulations where true MTD identified
A. Clinical trial dose toxicity curves | |||||
Dose escalation method | True dose toxicity curve | ||||
AZD3514 | AZD1208 | AZD1480 | AZD4877 | ||
3 + 3 | 64.9 | 50.5 | 45.5 | 100.0 | |
Extended CRM | Conservative | 71.7 | 66.8 | 60.9 | 100.0 |
Aggressive | 34.8 | 88.3 | 51.0 | 100.0 | |
Step-up | 57.6 | 88.9 | 60.1 | 100.0 | |
Dose-Linear | 36.4 | 98.5 | 60.4 | 100.0 | |
Sigmoidal | 71.4 | 66.8 | 68.4 | 100.0 | |
O’Quigley | 56.5 | 78.2 | 59.8 | 100.0 | |
B. Theoretical dose toxicity curves | |||||
Dose escalation method | True dose toxicity curve | ||||
Conservative | Step-up | Dose-linear | Sigmoidal | ||
3 + 3 | 33.1 | 22.7 | 36.8 | 46.6 | |
Extended CRM | Conservative | 63.4 | 43.9 | 53.9 | 50.3 |
Aggressive | 44.6 | 30.8 | 48.2 | 33.9 | |
Step-up | 44.5 | 29.8 | 64.2 | 32.6 | |
Dose-Linear | 39.7 | 23.6 | 62.7 | 22.8 | |
Sigmoidal | 51.7 | 33.0 | 67.8 | 33.2 | |
O’Quigley | 40.4 | 27.3 | 65.9 | 28.9 | |