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Table 4 Immune effects of the lymphocytes with altered abundance

From: The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma

Immune cells

Alteration in high risk group

Study

Basic function

Final effect to anticancer immune

T cells follicular helper

Increased

Vinuesa CG et al. [33].

TFH can develop humoral immunity by assisting the formation of germinal center.

Promotion

T cells regulatory

Increased

Juang CM et al. [34].

Tregs are suppressive T cells and can mediate immunosuppression and tumor immune evasion.

Suppression

Macrophages M2

Decreasing

Italiani P et al. [35].

M2 cells can promote tumor cells proliferation and repair through shifting the arginine metabolism to ornithine and polyamines.

Promotion

Dendritic cells resting

Decreasing

P Brossart et al. [36].

DCs are the most potent antigen-presenting cells with the ability to stimulate naive resting T cells and to initiate primary immune responses.

Suppression

Mast cells resting

Decreasing

Dyduch G et al. [37].

Mast cells play a pro-tumor or anti-tumor role by secreting different factors (VEGF, bFGF vs TNF-α, IL-1, IL-6)

Uncertain

  1. TFH T cells follicular helper, Tregs T cells regulatory, DCs Dendritic cells, VEGF vascular endothelial growth factor, bFGF basic fibroblast growth factor, TNF-α Tumor necrosis factor α, IL interleukin