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Table 4 Immune effects of the lymphocytes with altered abundance

From: The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma

Immune cells Alteration in high risk group Study Basic function Final effect to anticancer immune
T cells follicular helper Increased Vinuesa CG et al. [33]. TFH can develop humoral immunity by assisting the formation of germinal center. Promotion
T cells regulatory Increased Juang CM et al. [34]. Tregs are suppressive T cells and can mediate immunosuppression and tumor immune evasion. Suppression
Macrophages M2 Decreasing Italiani P et al. [35]. M2 cells can promote tumor cells proliferation and repair through shifting the arginine metabolism to ornithine and polyamines. Promotion
Dendritic cells resting Decreasing P Brossart et al. [36]. DCs are the most potent antigen-presenting cells with the ability to stimulate naive resting T cells and to initiate primary immune responses. Suppression
Mast cells resting Decreasing Dyduch G et al. [37]. Mast cells play a pro-tumor or anti-tumor role by secreting different factors (VEGF, bFGF vs TNF-α, IL-1, IL-6) Uncertain
  1. TFH T cells follicular helper, Tregs T cells regulatory, DCs Dendritic cells, VEGF vascular endothelial growth factor, bFGF basic fibroblast growth factor, TNF-α Tumor necrosis factor α, IL interleukin