Fig. 6From: Radotinib enhances cytarabine (Ara-C)-induced acute myeloid leukemia cell deathRadotinib and Ara-C inhibit tumor growth in a xenograft animal model using HEL92.1.7 cells. a Tumor volume (mm3) after radotinib and Ara-C treatment (n = 5 for each group). When the tumors were ~ 150 mm3 in size at ~ 7 days post-implantation, 0.2 ml radotinib (50 mg/kg body weight, PO) and Ara-C (50 mg/kg body weight, IP) were injected orally and intraperitoneally five times per week. Tumor sizes were measured once per week using digital calipers, and tumor volumes were calculated using the formula (length × width2) × 0.5. b Tumor weight (g) on day 24. c The body weight of mice. d, e The expression of diverse proteins including Bcl-xl, Cyclin E, PCNA, Bax, and p21 in the tumor. f The expression of TUNEL-positive cells in the tumor tissue. g The expression of PCNA-positive cells in the tumor tissue. These data represent the means ± SEM. Significantly different from the control (*); ***, P < 0.001Back to article page