Fig. 1
From: Radotinib enhances cytarabine (Ara-C)-induced acute myeloid leukemia cell death
Combination of radotinib and Ara-C enhances acute myeloid leukemia (AML) cell death. Cells were treated with 5 μM radotinib and/or 50 nM Ara-C for 48 h. The cytotoxicity was then evaluated by an MTS assay. a HL60 cells. b HEL92.1.7 cells. c THP-1 cells. d Bone marrow cells (BMCs) from AML patients (n = 5). e H209 cells. Representative data are shown from at least three independent experiments. These data represent the means ± SEM. Significantly different from control (*) or combination of radotinib and Ara-C (#); ***, ###: P < 0.001. R, radotinib; A, Ara-C; R + A, combination of radotinib and Ara-C