Table 2 Univariate analysis of the expression of ADHs expression with OS and RFS in 269 patients with HCC

Gender (males vs. females)

0.904 (0.560–1.458)

0.678

0.798 (0.495–1.288)

0.356

Age (≤ 60 vs. > 60 years)

1.361 (0.856–2.162)

0.193

1.314 (0.827–2.089)

0.247

Histologic grade

Low (Grade 1 + 2) vs. High (Grade 3 + 4)

1.051 (0.660–1.674)

0.833

1.144 (0.719–1.821)

0.571

Pathologic T stage

Low (T1 + 2) vs. High (T3 + 4)

3.819 (2.419–6.030)

8.86e-09

4.386 (2.766–6.952)

3.21e-10

Alcohol consumption (yes vs. no)

1.279 (0.795–2.058)

3.10e-01

1.036 (0.646–1.662)

0.884

Tumor recurrence (yes vs. no)

2.279 (1.383–3.755)

0.001

4.201 (2.507–7.039)

5.06e-08

ADH1A expression (high vs. low)

0.436 (0.261–0.727)

0.001

0.415 (0.248–0.693)

0.0008

ADH1B expression (high vs. low)

0.641 (0.405–1.015)

0.058

0.609 (0.385–0.964)

0.034

ADH1C expression (high vs. low)

0.516 (0.300–0.888)

0.017

0.518 (0.301–0.892)

0.018

ADH4 expression (high vs. low)

0.380 (0.240–0.600)

3.41e-05

0.386 (0.245–0.609)

4.17e-05

ADH5 expression (high vs. low)

0.708 (0.436–1.148)

0.161

0.677 (0.418–1.096)

0.112

ADH6 expression (high vs. low)

0.544 (0.342–0.864)

0.009

0.558 (0.351–0.886)

0.013