Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma

BMC Cancer

Table 1 Association analysis between ADHs expression and clinicopathological variables in 269 HCC patients

Variables	ADH1A			ADH1B			ADH1C			ADH4			ADH5			ADH6
Variables	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p
All patients	112	157		174	95		87	182		186	83		114	155		143	126
Gender			0.685			0.261			0.391			0.029			0.105			0.003
Males	78	113		128	63		65	126		140	51		87	104		113	78
Females	34	44		46	32		22	56		46	32		27	51		30	48
Age (years)			0.216			0.015			0.050			0.018			0.007			0.462
< 60	46	77		70	53		32	91		76	47		41	82		62	61
≥ 60	66	80		104	42		55	91		110	36		73	73		81	65
Histologic grade			0.005			0.0009			0.060			0.001			0.800			0.165
Low (Grade 1 + 2)	82	88		123	47		62	108		130	40		71	99		96	74
High (Grade 3 + 4)	30	69		51	48		25	74		56	43		43	56		47	52
Pathologic T stage			0.004			0.032			0.466			0.039			0.680			0.274
Low (T 1 + 2)	92	103		134	61		66	129		142	53		81	114		108	87
High (T 3 + 4)	20	54		40	34		21	53		44	30		33	41		35	39
Alcohol consumption			> 0.999			0.790			0.785			0.054			0.439
Yes	39	55		62	32		29	65		72	22		43	51		52	42	0.611
No	73	102		112	63		58	117		114	61		71	104		91	84
Tumor recurrence			0.269			0.899			0.118			0.088			0.805			0.903
Yes	50	81		84	47		36	95		84	47		57	74		69	62
No	62	76		90	48		51	87		102	36		57	81		74	64

ISSN: 1471-2407