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Fig. 7 | BMC Cancer

Fig. 7

From: MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway

Fig. 7

MNAT1 regulated OS chemo-sensitivity to DDP-based therapy. U2OS and 143B cells were transfected with si-NC, si-MNAT1, VECTOR or MNAT1 plasmid. After 48 h cells were treated with different concentration of DDP. a and b Cell viability analysis of U2OS and 143B cells treated with si-MNAT1 or MNAT1 plasmid and different concentrations of DDP in comparison with the negative control. c and d Cell viability analysis of U2OS and 143B cells treated with PI3K inhibitor PF-04979064 or MNAT1 plasmid and different concentrations of DDP in comparison with the negative control. e and f Colony formation (Scale bars, 8 mm) and EdU assay (Scale bars, 50 μm) performed on U2OS cells treated with si-MNAT1 or MNAT1 plasmid and different concentration of DDP in comparison with the negative control

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BMC Cancer

ISSN: 1471-2407

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