Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer

Table 3 Cox proportional hazards regression analysis in all cancers (n = 6412 to 9708), ERG-negative (n = 2880 to 4550), and ERG-positive cancers (n = 2331 to 3531)

Tumor subset	Scenario	n analyzable	p -value
Tumor subset	Scenario	n analyzable	preoperative PSA-Level	pT Stage	cT Stage	Gleason grade prostatectomy	Gleason grade biopsy	pN Stage	R Stage	ESRP1-Expression	ESRP2-Expression	ESRP1/ ESRP2 Score
all cancers	1	6412	< 0.0001	< 0.0001	–	< 0.0001	–	< 0.0001	0.0003	0.0014	0.0002	< 0.0001
	2	9708	< 0.0001	< 0.0001		< 0.0001			< 0.0001	0.0006	0.0004	< 0.0001
	3	9565	< 0.0001		< 0.0001	< 0.0001				0.0008	0.0006	0.0001
	4	8133	< 0.0001		< 0.0001		< 0.0001			< 0.0001	< 0.0001	< 0.0001
ERG-negative cancers	1	2880	< 0.0001	< 0.0001		< 0.0001		< 0.0001	0.0775	0.0120	0.0017	0.0028
	2	4299	< 0.0001	< 0.0001		< 0.0001			0.0002	0.0079	0.0019	0.0095
	3	4245	< 0.0001		< 0.0001	< 0.0001				0.0050	0.0013	0.0073
	4	4550	< 0.0001		< 0.0001		< 0.0001			< 0.0001	< 0.0001	< 0.0001
ERG-positive cancers	1	2331	< 0.0001	< 0.0001		< 0.0001		< 0.0001	0.0003	0.0305	0.0688	0.0008
	2	3531	< 0.0001	< 0.0001		< 0.0001		< 0.0001	< 0.0001	0.0033	0.1063	0.0004
	3	3464	< 0.0001		< 0.0001	< 0.0001				0.0083	0.2992	0.0013
	4	2991	< 0.0001		< 0.0001		< 0.0001			0.0002	0.8306	0.0004

ISSN: 1471-2407