Fig. 3

Cell proliferation under Taxol (paclitaxel) drug treatment. a Comparison of experimental data and simulation results for normalized cell viability of HeLa-C3 cells at different time points, (b) Contours plots of bound Taxol concentration in the cells at the centre slice of simulated spheroid at different time points, (c) Comparison of experimental data and simulation results for spatial activity of cisplatin at different time points and (d) Heat map of ratio of dead to live cells found at different areas of spheroids treated with cisplatin and Taxol at different time points. Green spots in the experimental panel of (c) indicate live cells, cyan spots indicate dead cells due to apoptosis alone and red spots indicate dead cells from apoptosis triggered by cisplatin. Green spots in the simulation panel of (c) indicate live cells and red spots indicate dead cells. The color bar in (d) indicates the dead to live cell ratio. GraphPad Prism v6.01 was used to generate plot (a). Tecplot 360 2018 R1 01 was used to generate plots (b) and (c) simulations subplot. Matplotlib v3.3.2 was used to generate plot (d)