Fig. 3
From: Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment
Expression levels of CA9 related gene in deferoxamine-treated MDA-MB-231 and MCF-7 cells as measured by RT-PCR (a). DFO upregulated CA9 expression in both MDA-MB-231 and MCF-7 cells, indicating that iron deficiency induces hypoxia. Expression levels of VEGFR2 related gene in deferoxamine-treated MDA-MB-231 and MCF-7 cells as measured by RT-PCR (b). Deferoxamine treatment increased KDR expression levels in MDA-MB-231 and MCF-7 cells. Expression levels of N-cadherin related gene in deferoxamine-treated MDA-MB-231 and MCF-7 cells as measured by RT-PCR (c). Deferoxamine treatment increased CDH2 expression levels in MDA-MB-231 and MCF-7 cells. Expression levels of PD-L1 related gene in deferoxamine-treated MDA-MB-231 and MCF-7 cells as measured by RT-PCR (d). Deferoxamine treatment increased CD274 expression levels in MDA-MB-231 and MCF-7 cells