Fig. 5
From: EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells
Combined treatment with EZH2 inhibitors and gefitinb inhibits EGFR wild-type NSCLC cell migration in vitro. a-b The effects of different drug treatments on cell migration of H1299 cells was detected by wound healing assay .Representative images are displayed at 4× magnification. Scale bar = 800 μm. Data are presented as mean ± standard deviation (SD). * P < 0.05, ** P < 0.01. c-d Transwell assay were performed to evaluate the migration ability of H1299 cells treated with different drug. Data are presented as mean ± SD. Scale bar = 200 μm, and images were are displayed at 20× magnification, * P < 0.05, ** P < 0.01. e The expression of MMP2, vimintin and N-cadherin in H1299 cells after treatment was detected by western blotting