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Table 3 Multivariate analysis of all characteristics on overall survival

From: CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

Variable pre-HR (95% CI) P value post-HR (95% CI) P value diff-HR (95% CI) P value
Age 1.049 (0.565, 1.948) 0.879 0.569 (0.254, 1.272) 0.169 0.556 (0.242, 1.277) 0.166
Tumor Location   0.160*   0.020*   0.318*
 Upper third 1   1   1  
 GEJ 0.298 (0.048, 1.849) 0.194 0.470 (0.060, 3.698) 0.473 0.314 (0.025, 3.883) 0.367
 Middle third 0.512 (0.186, 1.406) 0.194 0.108 (0.020, 0.586) 0.010 0.192 (0.031, 1.205) 0.078
 Lower third 0.532 (0.222, 1.278) 0.158 0.265 (0.083, 0.844) 0.025 0.542 (0.163, 1.801) 0.318
 Diffuse 1.170 (0.420, 3.259) 0.763 0.872 (0.261, 2.912) 0.824 0.876 (0.216, 3.556) 0.853
Tumor Depth (cm) 1.493 (0.738, 3.023) 0.265 1.695 (0.615, 4.669) 0.308 1.655 (0.610, 4.488) 0.322
ypT   0.425*   0.051*   0.109*
 0 1   1   1  
 1–2 0.212 (0.016, 2.860) 0.243 0.103 (0.005, 2.333) 0.153 0.129 (0.006, 2.933) 0.199
 3–4 0.414 (0.022, 7.627) 0.553 1.207 (0.020, 71.782) 0.928 1.018 (0.019, 55.965) 0.993
ypN   0.036*   0.003*   0.004*
 0 1   1   1  
 1 6.372 (1.280, 31.734) 0.024 45.419 (6.213, 332.002) 0.000 26.013 (3.647, 185.553) 0.001
 2 7.865 (1.399, 44.214) 0.019 36.926 (4.488, 303.797) 0.001 21.381 (2.539, 180.016) 0.005
 3 13.512 (2.217, 82.368) 0.005 49.034 (5.063, 474.881) 0.001 52.701 (5.358, 518.388) 0.001
ypTNM   0.759*   0.192*   0.256*
 I 1   1   1  
 II 1.449 (0.209, 10.075) 0.708 0.582 (0.031, 10.892) 0.718 0.571 (0.028, 11.584) 0.716
 III 0.927 (0.059, 14.55) 0.957 0.103 (0.002, 5.181) 0.256 0.114 (0.002, 5.424) 0.271
Histological type 0.583 (0.309, 1.097) 0.094 1.234 (0.562, 2.710) 0.600 1.168 (0.515, 2.648) 0.710
Lauren Classification 1.774 (0.972, 3.238) 0.062 0.919 (0.426, 1.982) 0.830 1.022 (0.422, 2.476) 0.961
Grade of differentiation 2.592 (1.074, 6.257) 0.034 3.495 (0.980, 12.457) 0.054 4.807 (1.345, 17.176) 0.016
VOLI 1.623 (0.925, 2.849) 0.091 4.532 (2.045, 10.043) 0.000 2.529 (1.005, 6.364) 0.049
NI 0.946 (0.543, 1.646) 0.843 0.957 (0.501, 1.829) 0.894 1.120 (0.544, 2.305) 0.758
Adjuvant therapy 3.421 (1.488, 7.866) 0.004 5.853 (1.919, 17.852) 0.002 7.236 (2.419, 21.647) 0.000
CEA 1.265 (0.712, 2.247) 0.423 1.105 (0.511, 2.390) 0.800 0.903 (0.399, 2.044) 0.807
CA199 0.984 (0.530, 1.829) 0.960 1.570 (0.606, 4.066) 0.353 1.032 (0.483, 2.206) 0.936
CA125 1.503 (0.821, 2.754) 0.187 1.492 (0.774, 2.878) 0.232 2.353 (1.068, 5.184) 0.034
CA724 2.177 (1.169, 4.056) 0.014 2.349 (1.057, 5.220) 0.036 1.238 (0.581, 2.638) 0.581
  1. VOLI Vascular or lymphatic invasion, NI Nervous invasion, GEJ Gastroesophageal junction; *P values from joint tests