Table 3 Multivariate analysis of all characteristics on overall survival

Age

1.049 (0.565, 1.948)

0.879

0.569 (0.254, 1.272)

0.169

0.556 (0.242, 1.277)

0.166

Tumor Location

0.160^*

0.020^*

0.318^*

 Upper third

1

1

1

 GEJ

0.298 (0.048, 1.849)

0.194

0.470 (0.060, 3.698)

0.473

0.314 (0.025, 3.883)

0.367

 Middle third

0.512 (0.186, 1.406)

0.194

0.108 (0.020, 0.586)

0.010

0.192 (0.031, 1.205)

0.078

 Lower third

0.532 (0.222, 1.278)

0.158

0.265 (0.083, 0.844)

0.025

0.542 (0.163, 1.801)

0.318

 Diffuse

1.170 (0.420, 3.259)

0.763

0.872 (0.261, 2.912)

0.824

0.876 (0.216, 3.556)

0.853

Tumor Depth (cm)

1.493 (0.738, 3.023)

0.265

1.695 (0.615, 4.669)

0.308

1.655 (0.610, 4.488)

0.322

ypT

0.425^*

0.051^*

0.109^*

 0

1

1

1

 1–2

0.212 (0.016, 2.860)

0.243

0.103 (0.005, 2.333)

0.153

0.129 (0.006, 2.933)

0.199

 3–4

0.414 (0.022, 7.627)

0.553

1.207 (0.020, 71.782)

0.928

1.018 (0.019, 55.965)

0.993

ypN

0.036^*

0.003^*

0.004^*

 0

1

1

1

 1

6.372 (1.280, 31.734)

0.024

45.419 (6.213, 332.002)

0.000

26.013 (3.647, 185.553)

0.001

 2

7.865 (1.399, 44.214)

0.019

36.926 (4.488, 303.797)

0.001

21.381 (2.539, 180.016)

0.005

 3

13.512 (2.217, 82.368)

0.005

49.034 (5.063, 474.881)

0.001

52.701 (5.358, 518.388)

0.001

ypTNM

0.759^*

0.192^*

0.256^*

 I

1

1

1

 II

1.449 (0.209, 10.075)

0.708

0.582 (0.031, 10.892)

0.718

0.571 (0.028, 11.584)

0.716

 III

0.927 (0.059, 14.55)

0.957

0.103 (0.002, 5.181)

0.256

0.114 (0.002, 5.424)

0.271

Histological type

0.583 (0.309, 1.097)

0.094

1.234 (0.562, 2.710)

0.600

1.168 (0.515, 2.648)

0.710

Lauren Classification

1.774 (0.972, 3.238)

0.062

0.919 (0.426, 1.982)

0.830

1.022 (0.422, 2.476)

0.961

Grade of differentiation

2.592 (1.074, 6.257)

0.034

3.495 (0.980, 12.457)

0.054

4.807 (1.345, 17.176)

0.016

VOLI

1.623 (0.925, 2.849)

0.091

4.532 (2.045, 10.043)

0.000

2.529 (1.005, 6.364)

0.049

NI

0.946 (0.543, 1.646)

0.843

0.957 (0.501, 1.829)

0.894

1.120 (0.544, 2.305)

0.758

Adjuvant therapy

3.421 (1.488, 7.866)

0.004

5.853 (1.919, 17.852)

0.002

7.236 (2.419, 21.647)

0.000

CEA

1.265 (0.712, 2.247)

0.423

1.105 (0.511, 2.390)

0.800

0.903 (0.399, 2.044)

0.807

CA199

0.984 (0.530, 1.829)

0.960

1.570 (0.606, 4.066)

0.353

1.032 (0.483, 2.206)

0.936

CA125

1.503 (0.821, 2.754)

0.187

1.492 (0.774, 2.878)

0.232

2.353 (1.068, 5.184)

0.034

CA724

2.177 (1.169, 4.056)

0.014

2.349 (1.057, 5.220)

0.036

1.238 (0.581, 2.638)

0.581