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Table 3 Hazard ratios and 95% confidence interval (CI) for risk of PLC among participants stratified by hs-CRP subgroups in different regression models

From: A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

 

hs-CRP

< 1 mg/L

1–3 mg/L

> 3 mg/L

P for trend

P for interaction

Sex

 Men

1.00(Ref.)

1.14 (0.86 ~ 1.51)

1.52 (1.15 ~ 2.00)

0.0076

0.1433

 Women

1.00(Ref.)

1.03 (0.82 ~ 1.36)

1.13 (1.01 ~ 1.29)

0.0121

Age

 ≤ 45

1.00(Ref.)

1.25 (0.53 ~ 2.95)

1.38 (0.63 ~ 3.03)

0.7209

< 0.001

 45 ~ 60

1.00(Ref.)

1.20 (0.84 ~ 1.70)

1.41 (1.01 ~ 2.00)

0.0199

 ≥ 60

1.00(Ref.)

0.83 (0.48 ~ 1.44)

1.54 (1.02 ~ 2.11)

0.2235

HBV infection

 (−)

1.00(Ref.)

0.94 (0.65 ~ 1.36)

1.46 (1.04 ~ 2.04)

0.0184

0.1570

 (+)

1.00(Ref.)

1.57 (1.03 ~ 2.40)

1.76 (1.14 ~ 2.72)

0.0309

Cirrhosis

 (−)

1.00(Ref.)

1.12 (0.85 ~ 1.49)

1.55 (1.18 ~ 2.03)

0.0037

0.1638

 (+)

1.00(Ref.)

0.89 (0.60 ~ 1.31)

1.10 (1.01 ~ 1.21)

0.0079

  1. All analyses were adjusted for age, BMI, ALT, NAFLD, HBV infection, cirrhosis, diabetes mellitus, family history of cancer, smoking status, drinking status and physical activity when participants were stratified by sex
  2. All analyses were adjusted for sex, BMI, ALT, NAFLD, HBV infection, cirrhosis, diabetes mellitus, family history of cancer, smoking status, drinking status and physical activity when participants were stratified by age
  3. All analyses were adjusted for sex, age, BMI, ALT, NAFLD, cirrhosis, diabetes mellitus, family history of cancer, smoking status, drinking status and physical activity when participants were stratified by HBV infection
  4. All analyses were adjusted for sex, age, BMI, ALT, NAFLD, HBV infection, diabetes mellitus, family history of cancer, smoking status, drinking status and physical activity when participants were stratified by cirrhosis