A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

Table 2 Hazard ratios and 95% confidence interval (CI) for risk of PLC among participants stratified by hs-CRP subgroups in different regression models

	hs-CRP
	< 1 mg/L	1–3 mg/L	> 3 mg/L	P for trend
Multivariate COX Regression
Cases	183	89	85
Person-years	573,524	264,335	197,180
Model 1	1.00(Ref.)	1.08 (0.84 ~ 1.40)	1.38 (1.06 ~ 1.81)	0.0616
Model 2	1.00(Ref.)	1.09 (0.84 ~ 1.41)	1.41 (1.08 ~ 1.85)	0.0428
Model 3	1.00(Ref.)	1.07 (0.82 ~ 1.38)	1.51 (1.15 ~ 1.98)	0.0121
CS Model
Cases	183	89	85
Person-years	573,524	264,335	197,180
Model 1	1.00(Ref.)	1.08 (0.84 ~ 1.40)	1.38 (1.06 ~ 1.81)	0.0616
Model 2	1.00(Ref.)	1.08 (0.84 ~ 1.41)	1.41 (1.08 ~ 1.85)	0.0428
Model 3	1.00(Ref.)	1.06 (0.81 ~ 1.40)	1.50 (1.14 ~ 1.99)	0.0133
SD Model
Cases	183	89	85
Person-years	573,524	264,335	197,180
Model 1	1.00(Ref.)	1.07 (0.83 ~ 1.39)	1.36 (1.04 ~ 1.79)	0.0780
Model 2	1.00(Ref.)	1.08 (0.84 ~ 1.40)	1.39 (1.06 ~ 1.82)	0.0554
Model 3	1.00(Ref.)	1.05 (0.80 ~ 1.40)	1.49 (1.13 ~ 1.98)	0.0151

Model 1: Univariate analysis
Model 2: Adjusted for age, sex based on model 1
Model 3: Further adjusted for BMI, ALT, cirrhosis, hepatitis B virus infection, NAFLD, adiabetes mellitus, family history of cancer, smoking status, drinking status, physical activity based on model 2
CS model: In cause-specific hazard model; SD: sub-distribution hazard function model

ISSN: 1471-2407