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Table 8 Adverse events following addition of carboplatin/gemcitabine combination as second-line NACT in the “intervention” group

From: Addition of carboplatin-gemcitabine as second-line neoadjuvant chemotherapy in non-responsive locally advanced breast cancer patients to standard neoadjuvant chemotherapy and evaluation of factors affecting response: a randomized controlled trial

Adverse event

Grade 1

Grade 2

Grade 3

Grade 4

Anemia

10 (40)

10 (40)

ALT rise

10 (40)

7 (28)

1 (4)

AST rise

8 (32)

2 (8)

ALP rise

5 (20)

Neutropenia (↓ANC)

6 (24)

7 (28)

3 (12)

Leukopenia

13 (52)

4 (16)

2 (8)

Thrombocytopenia

10 (40)

1 (4)

1 (4)

Oral mucositis

1 (4)

  1. ALT alanine amino transferase, AST aspartate amino transferase, ALP alkaline phosphatase, ANC absolute neutrophil count