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Table 5 Univariate analysis of pCR according to breast cancer molecular expressions and TILs

From: Addition of carboplatin-gemcitabine as second-line neoadjuvant chemotherapy in non-responsive locally advanced breast cancer patients to standard neoadjuvant chemotherapy and evaluation of factors affecting response: a randomized controlled trial

Group

pCR

Covariate

P value

  

Molecular subtypes

 

HR+/HER2-

HR+/HER2+

HR-/HER2+

TNBC

Intervention

 

n = 9

n = 12

n = 2

n = 2

 
 

+

0

7 (58.3)

0

1 (50.0)

0.014

-

9 (100.0)

5 (41.7)

2 (100.0)

1 (50.0)

Control

 

n = 12

n = 11

n = 2

n = 2

 
 

+

1 (8.3)

5 (45.5)

1 (50.0)

1 (50.0)

0.125

-

11 (91.7)

6 (54.5)

1 (50.0)

1 (50.0)

Total

 

n = 21

n = 23

n = 4

n = 4

 
 

+

1 (4.8)

12 (52.2)

1 (25.0)

2 (50.0)

0.002

-

20 (95.2)

11 (47.8)

3 (75.0)

2 (50.0)

  

ER Status

 

positive

negative

Intervention

 

n = 21

n = 4

 
 

+

7 (33.3)

1 (25.0)

1.00

-

14 (66.7)

3 (75.0)

Control

 

n = 23

n = 4

 
 

+

6 (26.1)

2 (50.0)

0.558

-

17 (73.9)

2 (50.0)

Total

 

n = 44

n = 8

 
 

+

13 (29.5)

3 (37.5)

0.689

-

31 (70.5)

5 (62.5)

  

PR Status

 

positive

negative

 

Intervention

 

n = 14

n = 11

 
 

+

4 (28.6)

4 (36.3)

1.00

-

10 (71.4)

7 (63.6)

Control

 

n = 19

n = 8

 
 

+

5 (26.3)

3 (37.5)

0.658

-

14 (73.7)

5 (62.5)

Total

 

n = 33

n = 19

 
 

+

9 (27.3)

7 (36.8)

0.472

-

24 (72.7)

12 (63.1)

  

HER2 Status

 

positive

negative

 

Intervention

 

n = 10

n = 15

 
 

+

5 (50.0)

3 (20.0)

0.194

-

5 (50.0)

12 (80.0)

Control

 

n = 8

n = 19

 
 

+

5 (62.5)

3 (15.8)

0.027

-

3 (37.5)

16 (84.2)

Total

 

n = 18

n = 34

 
 

+

10 (55.5)

6 (17.6)

0.005

-

8 (44.4)

28 (82.3)

  

ki67 status

 

positive

negative

 

Intervention

 

n = 19

n = 6

 
 

+

8 (42.1)

0 (0)

0.129

-

11 (57.9)

6 (100.0)

Control

 

n = 15

n = 12

 
 

+

6 (40.0)

2 (16.7)

0.236

-

9 (60.0)

10 (83.3)

Total

 

n = 34

n = 18

 
 

+

14 (41.2)

2 (11.1)

0.025

-

20 (58.8)

16 (88.9)

  

TILS

 

positive

negative

 

Intervention

 

n = 10

n = 15

 
 

+

6 (60.0)

2 (13.3)

0.028

-

4 (40.0)

13 (86.7)

Control

 

n = 13

n = 14

 
 

+

5 (38.5)

3 (21.4)

0.420

-

8 (61.5)

11 (78.6)

Total

 

n = 23

n = 29

 
 

+

11 (47.8)

5 (17.2)

0.018

-

12 (52.2)

24 (82.7)

  1. TNBC triple negative breast cancer, pCR pathologic complete response, ER estrogen receptor, PR progesterone receptor, TILs Tumor-infiltrating lymphocytes
  2. Note: + stands for pCR, - stands for non-pCR
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