|
Group
|
pCR
|
Covariate
|
P value
|
|---|
| | |
Molecular subtypes
| |
|
HR+/HER2-
|
HR+/HER2+
|
HR-/HER2+
|
TNBC
|
|
Intervention
| |
n = 9
|
n = 12
|
n = 2
|
n = 2
| |
| |
+
|
0
|
7 (58.3)
|
0
|
1 (50.0)
|
0.014
|
|
-
|
9 (100.0)
|
5 (41.7)
|
2 (100.0)
|
1 (50.0)
|
|
Control
| |
n = 12
|
n = 11
|
n = 2
|
n = 2
| |
| |
+
|
1 (8.3)
|
5 (45.5)
|
1 (50.0)
|
1 (50.0)
|
0.125
|
|
-
|
11 (91.7)
|
6 (54.5)
|
1 (50.0)
|
1 (50.0)
|
|
Total
| |
n = 21
|
n = 23
|
n = 4
|
n = 4
| |
| |
+
|
1 (4.8)
|
12 (52.2)
|
1 (25.0)
|
2 (50.0)
|
0.002
|
|
-
|
20 (95.2)
|
11 (47.8)
|
3 (75.0)
|
2 (50.0)
|
| | |
ER Status
| |
|
positive
|
negative
|
|
Intervention
| |
n = 21
|
n = 4
| |
| |
+
|
7 (33.3)
|
1 (25.0)
|
1.00
|
|
-
|
14 (66.7)
|
3 (75.0)
|
|
Control
| |
n = 23
|
n = 4
| |
| |
+
|
6 (26.1)
|
2 (50.0)
|
0.558
|
|
-
|
17 (73.9)
|
2 (50.0)
|
|
Total
| |
n = 44
|
n = 8
| |
| |
+
|
13 (29.5)
|
3 (37.5)
|
0.689
|
|
-
|
31 (70.5)
|
5 (62.5)
|
| | |
PR Status
| |
|
positive
|
negative
| |
|
Intervention
| |
n = 14
|
n = 11
| |
| |
+
|
4 (28.6)
|
4 (36.3)
|
1.00
|
|
-
|
10 (71.4)
|
7 (63.6)
|
|
Control
| |
n = 19
|
n = 8
| |
| |
+
|
5 (26.3)
|
3 (37.5)
|
0.658
|
|
-
|
14 (73.7)
|
5 (62.5)
|
|
Total
| |
n = 33
|
n = 19
| |
| |
+
|
9 (27.3)
|
7 (36.8)
|
0.472
|
|
-
|
24 (72.7)
|
12 (63.1)
|
| | |
HER2 Status
| |
|
positive
|
negative
| |
|
Intervention
| |
n = 10
|
n = 15
| |
| |
+
|
5 (50.0)
|
3 (20.0)
|
0.194
|
|
-
|
5 (50.0)
|
12 (80.0)
|
|
Control
| |
n = 8
|
n = 19
| |
| |
+
|
5 (62.5)
|
3 (15.8)
|
0.027
|
|
-
|
3 (37.5)
|
16 (84.2)
|
|
Total
| |
n = 18
|
n = 34
| |
| |
+
|
10 (55.5)
|
6 (17.6)
|
0.005
|
|
-
|
8 (44.4)
|
28 (82.3)
|
| | |
ki67 status
| |
|
positive
|
negative
| |
|
Intervention
| |
n = 19
|
n = 6
| |
| |
+
|
8 (42.1)
|
0 (0)
|
0.129
|
|
-
|
11 (57.9)
|
6 (100.0)
|
|
Control
| |
n = 15
|
n = 12
| |
| |
+
|
6 (40.0)
|
2 (16.7)
|
0.236
|
|
-
|
9 (60.0)
|
10 (83.3)
|
|
Total
| |
n = 34
|
n = 18
| |
| |
+
|
14 (41.2)
|
2 (11.1)
|
0.025
|
|
-
|
20 (58.8)
|
16 (88.9)
|
| | |
TILS
| |
|
positive
|
negative
| |
|
Intervention
| |
n = 10
|
n = 15
| |
| |
+
|
6 (60.0)
|
2 (13.3)
|
0.028
|
|
-
|
4 (40.0)
|
13 (86.7)
|
|
Control
| |
n = 13
|
n = 14
| |
| |
+
|
5 (38.5)
|
3 (21.4)
|
0.420
|
|
-
|
8 (61.5)
|
11 (78.6)
|
|
Total
| |
n = 23
|
n = 29
| |
| |
+
|
11 (47.8)
|
5 (17.2)
|
0.018
|
|
-
|
12 (52.2)
|
24 (82.7)
|
- TNBC triple negative breast cancer, pCR pathologic complete response, ER estrogen receptor, PR progesterone receptor, TILs Tumor-infiltrating lymphocytes
- Note: + stands for pCR, - stands for non-pCR
