Table 2 Main characteristics of the studies examining the relationship between leptin, adiponectin gene polymorphism and HCC
Author, Year, Country | Study design | Case/control | Number | Matching variables | SNP | Samples source | Genotyping methods | Frequency of case genotype | Frequency of control genotype | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|
Amer, 2017, Egypt | C | HCC/Healthy controls | 150/100 | age, sex and smoking rate | rs7799039 (leptin gene) | blood | PCR-RFLP technique | AA = 60; AG = 69; GG = 21; G allele =111; A allele =189 | AA = 49; AG = 47; GG = 4; G allele =54; A allele =146 | 7 |
Zhang, 2018, China | C | HCC/Healthy controls | 575/921 | age and sex | rs7799039 (leptin gene) | blood | SNPscan™ | AA = 295; AG = 221; GG = 59; G allele = 339; A allele =811 | AA = 505; AG = 360; GG = 56; G allele = 472; A allele =1370 | 7 |
Cai, 2013 China | C | HCC/Healthy controls | 200/200 | age and sex | rs1501299 (adiponectin gene) | blood | DNA sequencing | TT = 12; TG = 60; GG = 128; G allele = 316; T allele =84 | TT = 39; TG = 69; GG = 92; G allele = 253; T allele =147 | 8 |