The impact of lifecourse socio-economic position and individual social mobility on breast cancer risk

Berger, Eloïse; Maitre, Noële; Romana Mancini, Francesca; Baglietto, Laura; Perduca, Vittorio; Colineaux, Hélène; Sieri, Sabina; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Vineis, Paolo; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Castagné, Raphaële; Delpierre, Cyrille

doi:10.1186/s12885-020-07648-w

BMC Cancer

Table 2 Cox proportional hazard regression of BC risk using data from multiple imputation in E3N (N = 83,436)

From: The impact of lifecourse socio-economic position and individual social mobility on breast cancer risk

		A. Father’s occupation^a		B. Education^b		C. Occupation^a
		Medium	Advantaged	Middle	High	Medium	Advantaged
		HR [95%CI]	HR [95%CI]	HR [95%CI]	HR [95%CI]	HR [95%CI]	HR [95%CI]
M1		1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.09 [1.01, 1.17]	1.21 [1.12, 1.30]	1.02 [0.96, 1.09]	1.08 [1.00, 1.17]
Health behaviours And Anthropometric factors	M1 + Alcohol consumption	1.00 [0.95, 1.06]	1.09 [1.02, 1.17]	1.09 [1.02, 1.17]	1.20 [1.11, 1.29]	1.02 [0.96, 1.09]	1.08 [1.00, 1.17]
	M1 + Smoking status	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.09 [1.02, 1.17]	1.21 [1.12, 1.30]	1.03 [0.96, 1.09]	1.08 [1.00, 1.17]
	M1 + Western diet pattern	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.10 [1.02, 1.18]	1.21 [1.13, 1.31]	1.03 [0.97, 1.09]	1.09 [1.00, 1.18]
	M1 + Physical activity	1.00 [0.94, 1.05]	1.09 [1.02, 1.17]	1.08 [1.00, 1.16]	1.18 [1.10, 1.28]	1.02 [0.96, 1.08]	1.07 [0.99, 1.16]
	M1 + Height	1.00 [0.94, 1.05]	1.09 [1.01, 1.17]	1.09 [1.01, 1.17]	1.19 [1.11, 1.28]	1.02 [0.96, 1.08]	1.07 [0.99, 1.16]
	M1 + Weight	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.10 [1.02, 1.18]	1.21 [1.13, 1.31]	1.03 [0.97, 1.09]	1.08 [1.00, 1.17]
M1 + all health behaviours and anthropometrics factors		1.00 [0.94, 1.05]	1.08 [1.01, 1.16]	1.08 [1.00, 1.16]	1.18 [1.09, 1.27]	1.02 [0.96, 1.08]	1.07 [0.99, 1.16]
Reproductive factors	M1 + Family history of ovarian cancer	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.09 [1.01, 1.17]	1.20 [1.12, 1.30]	1.02 [0.96, 1.09]	1.08 [1.00, 1.17]
	M1 + Family history of breast cancer	1.00 [0.94, 1.05]	1.09 [1.01, 1.17]	1.09 [1.01, 1.17]	1.19 [1.11, 1.29]	1.02 [0.96, 1.09]	1.08 [1.00, 1.17]
	M1 + MHT use	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.08 [1.01, 1.16]	1.20 [1.11, 1.29]	1.02 [0.96, 1.08]	1.08 [0.99, 1.16]
	M1 + Age at the first childbirth	0.99 [0.94, 1.05]	1.07 [1.00, 1.15]	1.07 [1.00, 1.15]	1.13 [1.04, 1.22]	1.01 [0.95, 1.07]	1.07 [0.98, 1.16]
	M1 + Breastfeeding	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.09 [1.02, 1.17]	1.21 [1.12, 1.30]	1.03 [0.97, 1.09]	1.08 [1.00, 1.17]
	M1 + Reproductive lifespan	1.00 [0.94, 1.05]	1.09 [1.02, 1.17]	1.08 [1.01, 1.16]	1.19 [1.11, 1.29]	1.02 [0.96, 1.08]	1.07 [0.99, 1.16]
	M1 + BC screening	1.00 [0.94, 1.05]	1.09 [1.02, 1.17]	1.08 [1.00, 1.16]	1.19 [1.10, 1.28]	1.02 [0.96, 1.08]	1.08 [1.00, 1.17]
	M1 + Postmenopausal status	1.00 [0.95, 1.06]	1.10 [1.02, 1.18]	1.08 [1.01, 1.16]	1.19 [1.11, 1.28]	1.02 [0.96, 1.08]	1.08 [1.00, 1.17]
Model 1 + all reproductive factors		0.98 [0.93, 1.04]	1.05 [0.98, 1.13]	1.03 [0.96, 1.11]	1.06 [0.99, 1.15]	0.99 [0.93, 1.05]	1.06 [0.98, 1.15]
M2		0.98 [0.93, 1.04]	1.04 [0.97, 1.12]	1.03 [0.96, 1.11]	1.06 [0.98, 1.14]	0.99 [0.93, 1.05]	1.05 [0.97, 1.14]

M1 is adjusted for age
^aReferent group: “Disadvantaged”
^bReferent group: “Low education”
M2 is fully adjusted model
Hazard ratio (HR) and confidence interval are reported for (A) father’s occupation (B) education and (C) occupation

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com