Table 2 Expression of Kv2.1 and Kv1.5 proteins and clinico-pathological features of patients with GC
From: Selective expression of KCNA5 and KCNB1 genes in gastric and colorectal carcinoma
Parameters | Kv2.1 protein, N = 40 (%) | P a | Kv1.5 protein, N = 40 (%) | P a | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Negative | Mildly Positive | Moderately Positive | Strongly Positive | Negative | Mildly positive | Moderately positive | Strongly positive | |||
Gender | ||||||||||
 Male | 8 (20) | 3 (7.5) | 10 (25) | 5 (12.5) | 0.36 | 6 (15) | 5 (12.5) | 11 (27.5) | 4 (10) | 0.64 |
 Female | 7 (17.5) | 3 (7.5) | 3 (7.5) | 1 (2.5) | 6 (15) | 2 (5) | 4 (10) | 2 (5) | ||
Age (years) | ||||||||||
 < 50 | 5 (12.5) | 2 (5) | 6 (15) | 2 (5) | 0.89 | 6 (15) | 2 (5) | 5 (12.5) | 2 (5) | 0.75 |
 ≥ 50 | 10 (25) | 4 (10) | 7 (17.5) | 4 (10) | 6 (15) | 5 (15.5) | 10 (25) | 4 (10) | ||
Lauren classification | ||||||||||
 Diffuse | 8 (20) | 3 (7.5) | 7 (17.5) | 2 (5) | 0.78 | 7 (17.5) | 4 (10) | 7 (17.5) | 2 (5) | 0.94 |
 Intestinal | 5 (12.5) | 3 (7.5) | 3 (7.5) | 3 (7.5) | 4 (10) | 2 (5) | 5 (12.5) | 3 (7.5) | ||
 Mixed | 2 (5) | 0 (0) | 3 (7.5) | 1 (2.5) | 1 (2.5) | 1 (2.5) | 3 (7.5) | 1 (2.5) | ||
Tumor localization | ||||||||||
 Antro-Pyloric | 4 (10.5) | 0 (0) | 4 (10.5) | 4 (10.5) | 0.09 | 1 (2.6) | 4 (10.5) | 5 (13.2) | 2 (5.3) | 0.36 |
 Cardia | 1 (2.6) | 2 (5.3) | 1 (2.6) | 0 (0) | 1 (2.6) | 1 (2.6) | 2 (5.3) | 0 (0) |  | |
 Antro-fundic | 9 (23.7) | 4 (10.5) | 8 (21.1) | 1 (2.6) | 9 (23.7) | 2 (5.3) | 7 (18.4) | 4 (10.5) |  | |
TNM classification | ||||||||||
 Early/localized stage (I, II) | 6 (19.4) | 4 (12.9) | 10 (32.3) | 4 (12.9) | 0.026 | 4 (12.9) | 5 (16.1) | 11 (35.5) | 4 (12.9) | 0.056 |
 Advanced/metastatic stage (III, VI) | 6 (19.4) | 0 (0) | 0 (0) | 1 (2.6) | 4 (12.9) | 1 (3.2) | 0 (0) | 2 (6.5) | ||
Differentiation | ||||||||||
 Poorly | 10 (25) | 3 (7.5) | 8 (20) | 2 (5) | 0.41 | 8 (20) | 5 (12.5) | 8 (20) | 2 (5) | 0.48 |
 Moderately | 3 (7.5) | 2 (5) | 4 (10) | 1 (2.5) | 2 (5) | 0 (0) | 5 (12.5) | 3 (7.5) | ||
 Well | 2 (5) | 1 (2.5) | 1 (2.5) | 3 (7.5) | 2 (5) | 2 (0) | 2 (5) | 1 (2.5) | ||
Tumour infiltration | ||||||||||
 pT1-T2 | 4 (12.9) | 3 (9.7) | 6 (19.4) | 3 (9.7) | 0.41 | 2 (6.5) | 3 (9.7) | 8 (25.8) | 3 (9.7) | 0.24 |
 pT3-T4 | 8 (25.8) | 1 (3.2) | 4 (12.9) | 2 (6.5) | 6 (19.4) | 3 (9.7) | 3 (9.7) | 3 (9.7) | ||
Metastasis | ||||||||||
 Absent | 11 (27.5) | 6 (15) | 13 (32.5) | 6 (15) | 0.06 | 9 (22.5) | 7 (17.5) | 15 (37.5) | 5 (12.5) | 0.087 |
 Present | 4 (10) | 0 (0) | 0 (0) | 0 (0) | 3 (7.5) | 0 (0) | 0 (0) | 1 (2.5) | ||