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Table 1 Retrospective studies based on the real world population

From: Radiotherapy plays an important role in improving the survival outcome in patients with T1–2N1M0 breast cancer – a joint analysis of 4262 real world cases from two institutions

Studies Study period Total number of patients Stage Group Breast cancer death HR (95%CI)
Hwang, 2013 [6] 1990–2004 112,154 I-II MRM ± RT 1.00
    BCS + RT 0.84 (0.78–0.91)
Agarwal, 2014 [7] 1998–2008 132,149 I-II (tumor size ≤4 cm) BCS + RT 1.00
   MRM without RT 1.31 (1.25–1.39)
   MRM + RT 1.47 (1.34–1.61)
Hartmann-Johnsen, 2015 [8] 1998–2008 13,015 I-II (T1–2N0-1M0) BCS + RT 1.00
   MRM ± RT 1.64 (1.43–1.88)
Hofvind, 2015 [9] 2005–2011 9.547 I-III BCS + RT 1.00
    MRM ± RT 1.7 (1.3–2.4)
van Maaren, 2016 [10] 2000–2004 37,207 I-II (T1–2N0-1M0) MRM ± RT 1.00
   BCS + RT 0.81 (0.78–0.85)
Christiansen, 2018 [11] 1995–2012 58,331 I-III BCS ± RT 1.00
    MRM ± RT 1.20 (1.15–1.25)
  1. Abbreviations: MRM Modified radical mastectomy, BCS Breast-conserving surgery, RT Radiotherapy
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