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Table 1 Retrospective studies based on the real world population

From: Radiotherapy plays an important role in improving the survival outcome in patients with T1–2N1M0 breast cancer – a joint analysis of 4262 real world cases from two institutions

Studies

Study period

Total number of patients

Stage

Group

Breast cancer death HR (95%CI)

Hwang, 2013 [6]

1990–2004

112,154

I-II

MRM ± RT

1.00

   

BCS + RT

0.84 (0.78–0.91)

Agarwal, 2014 [7]

1998–2008

132,149

I-II (tumor size ≤4 cm)

BCS + RT

1.00

  

MRM without RT

1.31 (1.25–1.39)

  

MRM + RT

1.47 (1.34–1.61)

Hartmann-Johnsen, 2015 [8]

1998–2008

13,015

I-II (T1–2N0-1M0)

BCS + RT

1.00

  

MRM ± RT

1.64 (1.43–1.88)

Hofvind, 2015 [9]

2005–2011

9.547

I-III

BCS + RT

1.00

   

MRM ± RT

1.7 (1.3–2.4)

van Maaren, 2016 [10]

2000–2004

37,207

I-II (T1–2N0-1M0)

MRM ± RT

1.00

  

BCS + RT

0.81 (0.78–0.85)

Christiansen, 2018 [11]

1995–2012

58,331

I-III

BCS ± RT

1.00

   

MRM ± RT

1.20 (1.15–1.25)

  1. Abbreviations: MRM Modified radical mastectomy, BCS Breast-conserving surgery, RT Radiotherapy