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Table 4 Multivariate analysis for prognostic factors

From: Impact of superselective intra-arterial and systemic chemoradiotherapy for gingival carcinoma; analysis of treatment outcomes and prognostic factors

Variables

OS

PFS

LC

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age, years

<  65

1

  

1

  

1

  

≥ 65

3.645

1.041–12.77

0.022

1.835

0.671–5.015

0.212

2.210

0.732–6.675

0.130

ECOG PS

0

1

  

1

  

1

  

>  1

1.956

0.807–4.738

0.144

2.865

1.125–7.298

0.032

2.521

0.935–6.801

0.074

Clinical stage

≤ stage 3

1

  

1

  

1

  

> stage 4

6.735

1.581–28.70

0.009

1.866

0.368–.465

0.459

2.609

0.462–14.73

0.284

T category

≤ T3

1

  

1

  

1

  

> T3

1.921

0.677–5.469

0.236

1.618

0.452–.785

0.437

1.513

0.417–5.480

0.512

N category

≤ N2b

1

  

1

  

1

  

> N2b

1.425

0.513–3.957

0.506

2.468

0.966–6.301

0.069

2.415

0.936–6.229

0.078

Chemotherapy

IACRT

1

  

1

  

1

  

SCRT

3.161

1.055–9.468

0.041

1.389

0.524–3.686

0.511

1.630

0.595–4.463

0.344

Prescribed total dose

≤60 Gy

1

  

1

  

1

  

> 60 Gy

1.992

0.718–5.533

0.174

1.715

0.674–4.359

0.262

1.438

0.543–3.808

0.468

  1. OS overall survival, LC local control, PFS progression-free survival, EOCG PS Eastern Cooperative Oncology Group performance status, RT radiation therapy, IACRT Intra-arterial chemoradiation, SCRT systemic chemoradiation therapy