The age threshold of the 8th edition AJCC classification is useful for indicating patients with aggressive papillary thyroid cancer in clinical practice

Table 4 Univariate logistic regression analysis of age > 55 years old as risk factor for more advanced PTC entities in terms of T, N and M stage. pNx (n = 22) and pMx (n = 54) were not included in the calculations. Descriptive data are presented as the number (percent), and the results were analyzed by Wald test

Covariate: > 55 years old	pT (n = 523):		OR	+ 95% CI	p-value
Covariate: > 55 years old	pT1 + pT2 (n = 505)	pT3 + pT4 (n = 18)	OR	+ 95% CI	p-value
< 55 years	302 (59.8)	4 (22.2)	5.21	1.69–16.04	0.001^a
> 55 years	203 (40.2)	14 (77.8)
	pN (n = 501):		OR	+ 95% CI	p-value
	pN0 (n = 350)	pN1 (n = 151)	OR	+ 95% CI	p-value
< 55 years	250 (71.4)	52 (34.4)	4.76	3.16–7.15	< 0.0001^a
> 55 years	100 (28.6)	99 (65.6)
	pM (n = 469):		OR	+ 95% CI	p-value
	pM0 (n = 450)	pM1 (n = 19)	OR	+ 95% CI	p-value
< 55 years	276 (61.3)	0 (0.0)	–	–	< 0.0001^a
> 55 years	174 (38.7)	19 (100.0)

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