The age threshold of the 8th edition AJCC classification is useful for indicating patients with aggressive papillary thyroid cancer in clinical practice

Table 3 Univariate logistic regression analysis of age > 45 years old as risk factor for more advanced PTC entities in terms of T, N and M stage. pNx (n = 22) and pMx (n = 54) were not included in the calculations. Descriptive data are presented as the number (percent), and the results were analyzed by Wald test

Covariate: > 45 years old	pT (n = 523):		OR	+ 95% CI	p-value
Covariate: > 45 years old	pT1 + pT2 (n = 505)	pT3 + pT4 (n = 18)	OR	+ 95% CI	p-value
< 45 years	191 (37.8)	2 (11.1)	4.87	1.10–21.39	0.021^a
> 45 years	314 (62.2)	16 (88.9)
	pN (n = 501):		OR	+ 95% CI	p-value
	pN0 (n = 350)	pN1 (n = 151)	OR	+ 95% CI	p-value
< 45 years	162 (46.3)	28 (18.5)	3.78	2.38–6.00	< 0.0001^a
> 45 years	188 (53.7)	123 (81.5)
	pM (n = 469):		OR	+ 95% CI	p-value
	pM0 (n = 450)	pM1 (n = 19)	OR	+ 95% CI	p-value
< 45 years	178 (39.6)	0 (0.0)	–	–	< 0.001^a
> 45 years	272 (60.4)	19 (100.0)

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