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Table 2 Demographic, clinical and histopathological features in PTC patients divided into two age subgroups according cut-off point 45 years old and cut-off point 55 years old. Data are presented as the mean ± SD or number (percent)

From: The age threshold of the 8th edition AJCC classification is useful for indicating patients with aggressive papillary thyroid cancer in clinical practice

Variables

Cut-off point 45 years old

Cut-off point 55 years old

PTC patients

<  45 years old

(n = 193)

PTC patients

>  45 years old

(n = 330)

p-value

PTC patients

< 55 years old

(n = 306)

PTC patients

>  55 years old

(n = 217)

p-value

Age (years)

33.49 + 7.51

59.67 + 9.42

< 0.0001a

39.65 + 10.22

64.61 + 7.61

< 0.0001a

Sex:

  

0.460

  

0.099

 Female

171 (88.6)

285 (86.4)

 

273 (89.2)

183 (84.3)

 

 Male

22 (11.4)

45 (13.6)

 

33 (10.8)

34 (15.7)

 

Diagnosis of thyroid malignancy:

  

0.014a

  

0.038a

 Before surgery

131 (67.9)

188 (57.0)

 

198 (64.7)

121 (55.8)

 

 After surgery

62 (32.1)

142 (43.0)

 

108 (35.3)

96 (44.2)

 

Type of surgery:

  

0.463

  

0.986

 Total

137 (71.0)

244 (73.9)

 

223 (72.9)

158 (72.8)

 

 Partial

56 (29.0)

86 (26.1)

 

83 (27.1)

59 (27.2)

 

Reoperation:

  

0.510

  

0.687

 No

140 (72.5)

248 (75.2)

 

229 (74.8)

159 (73.3)

 

 Yes

53 (27.5)

82 (24.8)

 

77 (25.2)

58 (26.7)

 

pTNM stage:

  

0.004a

  

0.0007a

 I

172 (89.1)

261 (79.1)

 

265 (86.6)

168 (77.4)

 

 II

20 (10.4

47 (14.2)

 

36 (11.8)

31 (14.3)

 

 III

1 (0.5)

14 (4.2)

 

5 (1.6)

10 (4.6)

 

 IV

0 (0.0)

8 (2.4)

 

0 (0.0)

8 (3.7)

 

Tumor stage (pT):

  

0.055

  

0.013a

 pT1a

72 (37.3)

136 (41.2)

 

120 (39.2)

88 (40.6)

 

 pT1b

101 (52.3)

135 (40.9)

 

150 (49.0)

86 (39,6)

 

 pT2

18 (9.3)

43 (13.0)

 

32 (10.5)

29 (13.4)

 

 pT3

1 (0.5)

8 (2.4)

 

3 (1.0)

6 (2.7)

 

 pT4a

0 (0.0)

3 (0.9)

 

0 (0.0)

3 (1.4)

 

 pT4b

1 (0.5)

5 (1.5)

 

1 (0.3)

5 (2.3)

 

Lymph node metastasis (pN):

  

< 0.0001a

  

< 0.0001a

 pN0

162 (83.9)

188 (57.0)

 

250 (81.7)

100 (46.1)

 

 pN1a

26 (13.5)

119 (36.1)

 

49 (16.0)

96 (44.2)

 

 pN1b

2 (1.0)

4 (1.2)

 

3 (1.0)

3 (1.4)

 

 pNx

3 (1.6)

19 (5.7)

 

4 (1.3)

18 (8.3)

 

Distant metastasis (pM):

  

0.002a

  

< 0.0001a

 pM0

178 (92.2)

272 (82.4)

 

276 (90.2)

174 (80.2)

 

 pM1

0 (0.0)

19 (5.8)

 

0 (0.0)

19 (8.8)

 

 pMx

15 (7.8)

39 (11.8)

 

30 (9.8)

24 (11.0)

 
  1. a- statistically significant