Table 5 Univariate and multivariate Cox proportional hazards regression analysis in infiltrating duct carcinoma patients with bone metastasis
Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) P value | HR (95% CI) P value | |||
Race | ||||
 Black | Reference |  | Reference |  |
 Other | 0.504 (0.359–0.707) | < 0.001 | 0.547 (0.387–0.772) | 0.001 |
 White | 0.695 (0.579–0.834) | < 0.001 | 0.686 (0.567–0.831) | < 0.001 |
Age | ||||
 22–54 | Reference |  | Reference |  |
 55–79 | 1.511 (1.296–1.763) | < 0.001 | 1.523 (1.302–1.782) | < 0.001 |
  ≥ 80 | 2.414 (1.942–3.001) | < 0.001 | 2.241 (1.768–2.841) | < 0.001 |
Sex | ||||
 Female | Reference |  |  |  |
 Male | 1.236 (0.801–1.906) | 0.338 |  |  |
Primary Site | ||||
 Nipple | Reference |  |  |  |
 Central portion of breast | 0.443 (0.204–0.961) | 0.039 |  |  |
 Upper-inner quadrant of breast | 0.557 (0.258–1.205) | 0.138 |  |  |
 Lower-inner quadrant of breast | 0.619 (0.283–1.353) | 0.229 |  |  |
 Upper-outer quadrant of breast | 0.591 (0.279–1.251) | 0.170 |  |  |
 Lower-outer quadrant of breast | 0.468 (0.214–1.024) | 0.057 |  |  |
 Axillary tail of breast | 0.339 (0.099–1.159) | 0.085 |  |  |
 Overlapping lesion of breast | 0.536 (0.253–1.139) | 0.105 |  |  |
Grade | ||||
 I | Reference |  | Reference |  |
 II | 1.658 (1.161–2.368) | 0.005 | 1.902 (1.329–2.721) | < 0.001 |
 III | 2.436 (1.710–3.470) | < 0.001 | 2.819 (1.958–4.057) | < 0.001 |
 IV | 4.156 (1.274–13.557) | 0.018 | 2.527 (0.761–8.395) | 0.13 |
Laterality | ||||
 Left - origin of primary | Reference |  |  |  |
 Right - origin of primary | 1.022 (0.893–1.169) | 0.752 |  |  |
T stage | ||||
 T1 | Reference |  |  |  |
 T2 | 0.945 (0.765–1.167) | 0.600 |  |  |
 T3 | 1.252 (0.988–1.585) | 0.063 |  |  |
 T4 | 1.237 (0.993–1.541) | 0.058 |  |  |
N stage | ||||
 N0 | Reference |  |  |  |
 N1 | 0.944 (0.796–1.120) | 0.511 |  |  |
 N2 | 0.916 (0.726–1.155) | 0.459 |  |  |
 N3 | 1.087 (0.875–1.350) | 0.451 |  |  |
Radiotherapy | ||||
 No | Reference |  |  |  |
 Yes | 0.735 (0.628–0.861) | < 0.001 |  |  |
Surgery | ||||
 No | Reference |  | Reference |  |
 Yes | 0.562 (0.487–0.648) | < 0.001 | 0.575 (0.493–0.669) | < 0.001 |
Chemotherapy | ||||
 No | Reference |  | Reference |  |
 Yes | 0.769 (0.672–0.880) | < 0.001 | 0.730 (0.619–0.860) | < 0.001 |
Brain metastasis | ||||
 No | Reference |  | Reference |  |
 Yes | 2.721 (2.132–3.473) | < 0.001 | 2.189 (1.699–2.820) | < 0.001 |
Liver metastasis | ||||
 No | Reference |  | Reference |  |
 Yes | 1.851 (1.584–2.163) | < 0.001 | 1.744 (1.471–2.067) | < 0.001 |
Lung metastasis | ||||
 No | Reference |  |  |  |
 Yes | 1.535 (1.325–1.778) | < 0.001 |  |  |
Breast subtype | ||||
 HR−/HER2- | Reference |  | Reference |  |
 HR−/HER2+ | 0.263 (0.186–0.372) | < 0.001 | 0.281 (0.198–0.399) | < 0.001 |
 HR+/HER2- | 0.337 (0.278–0.409) | < 0.001 | 0.376 (0.299–0.474) | < 0.001 |
 HR+/HER2+ | 0.304 (0.238–0.388) | < 0.001 | 0.312 (0.242–0.402) | < 0.001 |
HER2 status | ||||
 Positive | Reference |  |  |  |
 Negative | 1.322 (1.118–1.563) | =0.001 |  |  |
Insurance | ||||
 Uninsured | Reference |  | Reference |  |
 Insured | 0.684 (0.519–0.902) | 0.007 | 0.726 (0.545–0.966) | 0.028 |
Marital status | ||||
 Unmarried | Reference |  | Reference |  |
 Married | 0.757 (0.662–0.866) | < 0.001 | 0.860 (0.748–0.989) | 0.035 |