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Table 4 Multivariate logistic regression analysis of risk factor of bone metastasis in infiltrating duct carcinoma patients

From: Risk factors, prognostic factors, and nomograms for bone metastasis in patients with newly diagnosed infiltrating duct carcinoma of the breast: a population-based study

Variables

Multivariate logistic regression analysis

 

HR (95% CI)

P value

Sex

 Female

Reference

 Male

1.507 (1.052–2.159)

0.025

Primary Site

 Nipple

Reference

 

 Central portion of breast

1.169 (0.612–2.231)

0.636

 Upper-inner quadrant of breast

1.062 (0.555–2.031)

0.856

 Lower-inner quadrant of breast

1.442 (0.748–2.783)

0.275

 Upper-outer quadrant of breast

1.084 (0.573–2.047)

0.805

 Lower-outer quadrant of breast

1.033 (0.538–1.985)

0.922

 Axillary tail of breast

2.024 (0.900–4.552)

0.088

 Overlapping lesion of breast

1.178 (0.623–2.228)

0.614

Grade

 I

Reference

 

 II

1.801 (1.498–2.165)

< 0.001

 III

1.266 (1.043–1.537)

0.017

 IV

0.422 (0.127–1.402)

0.159

T stage

 T1

Reference

 

 T2

4.015 (3.499–4.607)

< 0.001

 T3

7.638 (6.417–9.091)

< 0.001

 T4

17.022 (14.330–20.218)

< 0.001

N stage

 N0

Reference

 

 N1

2.709 (2.408–3.047)

< 0.001

 N2

2.570 (2.174–3.038)

< 0.001

 N3

4.651 (3.912–5.529)

< 0.001

Brain metastasis

 No

Reference

 

 Yes

14.890 (10.102–21.947)

< 0.001

Liver metastasis

 No

Reference

 

 Yes

19.038 (16.042–22.593)

< 0.001

Lung metastasis

 No

Reference

 

 Yes

13.368 (11.400–15.675)

< 0.001

Breast Subtype

 HR−/HER2-

Reference

 

 HR−/HER2+

1.201 (0.938–1.539)

0.146

 HR+/HER2-

2.496 (2.096–2.972)

< 0.001

 HR+/HER2+

2.289 (1.886–2.778)

< 0.001

Race

 Black

Reference

0.005

 Other

0.811 (0.655–1.005)

0.055

 White

1.073 (0.928–1.240)

0.341

Insurance

 Uninsured

Reference

 

 Insured

0.686 (0.548–0.859)

0.001

Marital status

 Unmarried

Reference

 

 Married

0.861 (0.782–0.947)

0.002