Table 3 Diagnosis Characteristics of Choroidal Metastases in Seven Patients
Patients | Patient #1 | Patient #2 | Patient #3 | Patient #4 | Patient #5 | Patient #6 | Patient #7 |
|---|---|---|---|---|---|---|---|
Symptoms | Yes | Yes | Yes | Yes | Yes | Yes | No |
Time to onset of symptoms (months) | 0 | 0 | 0 | 0 | 0 | 0 | |
Nature of symptoms | Myodesopsia and visual acuity loss of right eye | Intermittent visual blur on right eye | Visual acuity loss of left eye | Visual acuity loss of right eye | Blurred vision in right eye | Retro-ocular pain and visual acuity loss on right eye | |
Associated metastatic site (yes / no) | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Associated brain metastases | No | Yes | No | Yes | Yes | Yes | Yes |
Diagnostic tool | Fundoscopic examination Fluorescein angiography B-scan ultrasound | Fundoscopic examination Fluorescein angiography B-scan ultrasound | B-scan ultrasound | Fundoscopic examination Fluorescein angiography B-scan ultrasound | Fundoscopic examination Fluorescein angiography B-scan ultrasound | B-scan ultrasound | Retrospective MRI analysis |
Uni- or bilateral lesion | Unilateral | Unilateral | Unilateral | Unilateral | Bilateral | Unilateral | Unilateral |
Visibility on MRI (yes / no) | Not performed | No | Yes | Yes | Yes | Yes | Yes |
Response to systemic therapy | Objective response to afatinib | Objective response to afatinib | Objective response to chemotherapy | Objective response to osimertinib | No | Not evaluable | Objective response to erlotinib |
Radiotherapy of choroidal metastases | No | No | No | No | Yes | No | No |
Concomitant progression to visceral progression | No | No | No | No | No | Not evaluable | No |