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Table 2 Univariable and multivariable Cox regression analyses of all patients for intravesical recurrence-free survival, recurrence-free survival, cancer-specific survival, and overall survival

From: Preoperative positive voided urine cytology predicts poor clinical outcomes in patients with upper tract urothelial carcinoma undergoing nephroureterectomy

Factors

Intravesical RFS

RFS

CSS

OS

Univariable

Multivariablea

Univariable

Multivariableb

Univariable

Multivariablec

Univariable

Multivariablec

P

HR(95%CI)

P

P

HR(95%CI)

P

P

HR(95%CI)

P

P

HR(95%CI)

P

Urine cytology (Yes VS. No)

0.073

2.21 (1.06–4.64)

0.035

0.009

1.80 (1.08–2.99)

0.023

0.019

1.87 (1.10–3.18)

0.020

0.057

1.32 (0.80–2.18)

0.28

Tumor stage (≥T3 VS. ≤T2)

0.5

 

0.28

<0.001

3.10 (1.74–5.52)

<0.001

<0.001

4.42 (2.38–8.23)

<0.001

<0.001

3.23 (1.80–5.78)

<0.001

Age (≥65 VS. <65)

0.3

 

0.6

0.001

2.45 (1.32–4.53)

0.004

0.002

2.05 (1.08–3.90)

0.029

0.002

2.09 (1.11–3.93)

0.022

Bladder irrigation (Yes VS. No)

0.25

 

0.15

0.20

 

0.25

0.050

0.51 (0.29–0.90)

0.021

0.024

0.53 (0.31–0.89)

0.017

LVI (Yes VS. No)

0.19

 

0.051

<0.001

2.66 (1.32–5.34)

0.006

<0.001

 

0.076

0.003

2.22 (1.14–4.33)

0.019

Hydronephrosis (Yes VS. No)

0.13

 

0.8

0.061

1.89 (1.04–3.43)

0.036

0.094

2.45 (1.30–4.60)

0.005

0.23

 

0.17

DM (Yes VS. No)

0.7

 

–

0.10

0.46 (0.21–0.99)

0.047

0.6

 

–

0.6

 

–

Location (ureter VS. pelvis)

0.028

3.00 (1.32–6.85)

0.009

0.21

 

0.4

0.23

 

0.4

0.8

 

0.3

Hypertension (Yes VS. No)

0.26

 

–

0.049

 

0.10

0.044

 

0.13

0.022

1.71 (1.01–2.86)

0.044

Gender (Male VS. Female)

0.7

 

–

0.8

 

–

0.6

 

0.5

0.21

 

0.091

Smoking (Yes VS. No)

0.6

 

0.8

0.5

 

0.4

0.6

 

0.6

0.9

 

0.8

BMI (≥30 VS. <30)

0.5

 

0.4

0.18

 

0.4

0.3

 

0.6

0.23

 

0.4

Multifocality (Yes VS. No)

0.4

 

0.6

0.034

 

0.13

0.12

 

0.29

0.22

 

0.7

Size (>2 CM VS. ≤2 CM)

0.7

 

0.3

0.9

 

0.4

1

 

0.8

1

 

0.9

Tumor grade (high VS. low)

0.4

 

0.8

0.014

 

0.11

0.018

 

0.063

0.027

 

0.23

Hematuria (Yes VS. No)

0.034

 

0.054

0.7

 

–

0.6

 

–

0.4

 

–

Alcohol history (Yes VS. No)

0.050

 

0.073

0.9

 

–

1

 

–

0.5

 

–

Preoperative URS

0.20

 

0.6

–

 

–

–

 

–

–

 

–

  1. Note: a Adjusted for tumor stage, age, bladder irrigation, LVI, hydronephrosis, location, smoking, BMI, multifocality, size, tumor grade, hematuria, alcohol history, and URS;
  2. b Adjusted for tumor stage, age, bladder irrigation, LVI, hydronephrosis, DM, location, hypertension, smoking, BMI, multifocality, size, and tumor grade;
  3. c Adjusted for tumor stage, age, bladder irrigation, LVI, hydronephrosis, location, hypertension, gender, smoking, BMI, multifocality, size, and tumor grade;
  4. Abbreviations: RFS Recurrence-free survival, CSS Cancer-specific survival; OS Overall survival, DM Diabetes mellitus; BMI Body mass index; LVI Lymphovascular invasion; URS Ureteroscopy, HR Hazard ratio
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BMC Cancer

ISSN: 1471-2407

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