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Table 2 Univariate and multivariate analysis of clinical and pathologicalal response rates by biological factors

From: Nomogram-derived prediction of pathologic complete response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy (NCT)

Factors

Univariate analysis

Multivariate analysis

OR

95%CI

P-value

OR

95%CI

P-value

age (years)

  ≤ 45

Ref

     

  > 45

0.792

0.394–1.593

0.513

   

BMI (kg/m2)

  < 25

Ref

     

  ≥ 25

1.384

0.617–3.102

0.430

   

Menopausal status

 Postmenopausal

Ref

     

 Premenopausal

1.130

0.569–2.245

0.726

   

Multifocality

 Multifocal

Ref

     

 Unifocal

0.821

0.353–1.911

0.648

   

Local invasion

 Yes

Ref

     

 No

0.432

0.051–3.690

0.443

   

LVI

 Absent

Ref

     

 Present

0.292

0.106–0.800

0.017

0.314

0.108–0.918

0.034

Clinical tumor size

 T1

Ref

     

 T2

0.762

0.267–2.173

0.533

   

 T3

0.948

0.255–3.525

0.875

   

Lymph node status

 N0

Ref

     

 N1–2

1.185

0.560–2.507

0.657

   

Histological grade

 I-II

Ref

     

 III

1.427

0.667–3.054

0.360

   

Histologic type

 IDC

Ref.

 

.

   

 Others

4.889

0.617–38.739

0.133

   

Progesterone receptor

 Negative

Ref.

 

.

   

 Positive

0.451

0.222–0.917

0.028

   

Estrogen receptor

 Negative

Ref

  

Ref

  

 Positive

0.286

0.118–0.694

0.006

0.342

0.132–0.889

0.028

Hormone receptor

 Negative

Ref

     

 Positive

0.497

0.246–1.002

0.051

   

HER2

 Negative

Ref

     

 Positive

1.833

0.914–3.678

0.088

   

Ki67

  ≤ 60%

Ref.

 

.

Ref

  

  > 60%

0.363

0.175–0.751

0.006

0.258

0.106–0.627

0.003

Molecular subtype

 Luminal B

Ref.

 

.

   

 HER2 enriched

0.072

0.016–0.324

0.001

   

 Triple negative

0.711

0.331–1.527

0.046

   

NCT regimen

 TEC

Ref

  

Ref

  

 TCbH

2.228

1.103–4.501

0.025

3.268

1.380–7.738

0.007

NCT time, cycles

  ≤ 4

Ref.

 

.

   

  > 4

0.390

0.127–1.196

0.100

   

Hemoglobin(g/L)

  ≤ 120

Ref

     

  > 120

0.359

0.140–0.923

0.033

0.423

0.154–0.988

0.046

  1. Abbreviations: OR odds ratio, CI confidence interval, BMI body mass index, pCR pathologic complete response, NCT Neoadjuvant chemotherapy, IDC Invasive ductal carcinoma, HER2 Human epidermal growth factor receptor, LVI lymphovascular invasion, Others: invasive lobular carcinoma, metaplastic carcinoma and medullary carcinoma
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BMC Cancer

ISSN: 1471-2407

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