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Table 3 Preceding Laboratory Values within Seven Days (N = 11,183 cultures)a

From: Development and utility assessment of a machine learning bloodstream infection classifier in pediatric patients receiving cancer treatments

 

Negative

Positive

P***

n

10,559

624

 

WBC, ANC and Neutropenia

 Mean WBC 0- < 24 Hours (SD)

8.39 (27.04)

4.38 (13.54)

< 0.001

 Mean WBC 24- < 48 Hours (SD)

5.52 (12.33)

1.67 (6.80)

< 0.001

 Mean Average WBC Prior 7 Days (SD)

8.24 (26.29)

4.70 (13.31)

0.001

 Mean Minimum WBC Prior 7 Days (SD)

6.90 (26.08)

3.73 (13.03)

0.003

 Mean ANC 0- < 24 Hours (SD)

4.15 (6.50)

2.66 (4.73)

< 0.001

 Mean ANC 24- < 48 Hours (SD)

3.38 (6.32)

1.10 (3.21)

< 0.001

 Mean Average ANC Prior 7 Days (SD)

3.96 (5.91)

2.73 (4.15)

< 0.001

 Mean Minimum ANC Prior 7 Days (SD)

3.00 (5.37)

1.90 (3.61)

< 0.001

 Number Neutropenic 0- < 24 Hours (%)b

2745 (26.0)

397 (63.6)

< 0.001

 Number Neutropenic 24- < 48 Hours (%)b

1146 (10.9)

253 (40.5)

< 0.001

Renal Function

 Mean BUN 0- < 24 Hours (SD)

4.41 (2.79)

4.88 (2.85)

0.001

 Mean BUN 24- < 48 Hours (SD)

4.65 (3.34)

5.22 (3.04)

0.011

 Mean Average BUN Prior 7 Days (SD)

4.47 (2.60)

4.86 (2.41)

0.001

 Mean Maximum BUN Prior 7 Days (SD)

5.07 (3.20)

5.66 (3.01)

< 0.001

 Mean Creatinine 0- < 24 Hours (SD)

37.35 (35.55)

34.16 (14.24)

0.039

 Mean Creatinine 24- < 48 Hours (SD)

36.32 (39.38)

34.25 (14.47)

0.367

 Mean Average Creatinine Prior 7 Days (SD)

36.93 (35.50)

34.18 (13.66)

0.062

 Mean Maximum Creatinine Prior 7 Days (SD)

39.67 (40.39)

37.93 (16.18)

0.299

 Renal Failure 0- < 24 Hours (%)b

122 (1.2)

2 (0.3)

0.082

 Renal Failure 24- < 48 Hours (%)b

48 (0.5)

1 (0.2)

0.441

 Renal Failure Prior 7 Days (%)

164 (1.6)

5 (0.8)

0.184

Other Laboratory Values

 Mean Albumen 0- < 24 Hours (SD)

35.02 (6.33)

34.22 (5.99)

0.102

 Mean Average Albumen Prior 7 Days (SD)

35.44 (6.13)

34.57 (5.36)

0.012

 Mean Minimum Albumen Prior 7 Days (SD)

34.08 (6.64)

33.01 (5.82)

0.005

 Mean ALT 0- < 24 Hours (SD)

81.28 (159.48)

78.32 (79.34)

0.785

 Mean Average ALT Prior 7 Days (SD)

77.01 (123.52)

78.70 (89.95)

0.781

 Mean Maximum Prior 7 Days ALT (SD)

87.07 (146.59)

92.97 (116.53)

0.415

 Mean Glucose 0- < 24 Hours (SD)

5.59 (2.31)

5.60 (1.83)

0.928

 Mean Glucose 24- < 48 Hours (SD)

5.51 (2.04)

5.64 (2.32)

0.310

 Mean Average Glucose Prior 7 Days (SD)

5.54 (1.64)

5.61 (1.40)

0.341

 Mean Minimum Glucose Prior 7 Days (SD)

5.09 (1.45)

4.93 (1.07)

0.013

 Mean Maximum Glucose Prior 7 Days (SD)

6.17 (3.01)

6.55 (2.79)

0.004

 Mean Sodium 0- < 24 Hours (SD)

138.22 (3.34)

137.54 (3.86)

< 0.001

 Mean Sodium 24- < 48 Hours (SD)

139.13 (3.38)

138.97 (3.27)

0.434

 Mean Average Sodium Prior 7 Days (SD)

138.62 (2.96)

138.27 (3.28)

0.006

 Mean Minimum Sodium Prior 7 Days (SD)

137.59 (3.20)

136.65 (3.68)

< 0.001

 Mean Maximum Sodium Prior 7 Days (SD)

139.65 (3.46)

139.82 (3.77)

0.255

  1. Abbreviations: SD Standard deviation, ANC Absolute neutrophil count, WBC White blood cell count, BUN Blood urea nitrogen, ALT Alanine aminotransferase
  2. a Units: WBC 109/L, ANC 109/L, BUN mmol/L, creatinine umol/L, albumen g/L, ALT U/L, glucose mmol/L, sodium mmol/L
  3. b Neutropenia defined as ANC < 0.5 × 109/L; renal failure defined as serum creatinine ≥1.5 times upper limit of normal
  4. *** P values calculated using Student’s t-test for continuous variables and chi square test for categorical variables