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Table 3 Preceding Laboratory Values within Seven Days (N = 11,183 cultures)a

From: Development and utility assessment of a machine learning bloodstream infection classifier in pediatric patients receiving cancer treatments

  Negative Positive P***
n 10,559 624  
WBC, ANC and Neutropenia
 Mean WBC 0- < 24 Hours (SD) 8.39 (27.04) 4.38 (13.54) < 0.001
 Mean WBC 24- < 48 Hours (SD) 5.52 (12.33) 1.67 (6.80) < 0.001
 Mean Average WBC Prior 7 Days (SD) 8.24 (26.29) 4.70 (13.31) 0.001
 Mean Minimum WBC Prior 7 Days (SD) 6.90 (26.08) 3.73 (13.03) 0.003
 Mean ANC 0- < 24 Hours (SD) 4.15 (6.50) 2.66 (4.73) < 0.001
 Mean ANC 24- < 48 Hours (SD) 3.38 (6.32) 1.10 (3.21) < 0.001
 Mean Average ANC Prior 7 Days (SD) 3.96 (5.91) 2.73 (4.15) < 0.001
 Mean Minimum ANC Prior 7 Days (SD) 3.00 (5.37) 1.90 (3.61) < 0.001
 Number Neutropenic 0- < 24 Hours (%)b 2745 (26.0) 397 (63.6) < 0.001
 Number Neutropenic 24- < 48 Hours (%)b 1146 (10.9) 253 (40.5) < 0.001
Renal Function
 Mean BUN 0- < 24 Hours (SD) 4.41 (2.79) 4.88 (2.85) 0.001
 Mean BUN 24- < 48 Hours (SD) 4.65 (3.34) 5.22 (3.04) 0.011
 Mean Average BUN Prior 7 Days (SD) 4.47 (2.60) 4.86 (2.41) 0.001
 Mean Maximum BUN Prior 7 Days (SD) 5.07 (3.20) 5.66 (3.01) < 0.001
 Mean Creatinine 0- < 24 Hours (SD) 37.35 (35.55) 34.16 (14.24) 0.039
 Mean Creatinine 24- < 48 Hours (SD) 36.32 (39.38) 34.25 (14.47) 0.367
 Mean Average Creatinine Prior 7 Days (SD) 36.93 (35.50) 34.18 (13.66) 0.062
 Mean Maximum Creatinine Prior 7 Days (SD) 39.67 (40.39) 37.93 (16.18) 0.299
 Renal Failure 0- < 24 Hours (%)b 122 (1.2) 2 (0.3) 0.082
 Renal Failure 24- < 48 Hours (%)b 48 (0.5) 1 (0.2) 0.441
 Renal Failure Prior 7 Days (%) 164 (1.6) 5 (0.8) 0.184
Other Laboratory Values
 Mean Albumen 0- < 24 Hours (SD) 35.02 (6.33) 34.22 (5.99) 0.102
 Mean Average Albumen Prior 7 Days (SD) 35.44 (6.13) 34.57 (5.36) 0.012
 Mean Minimum Albumen Prior 7 Days (SD) 34.08 (6.64) 33.01 (5.82) 0.005
 Mean ALT 0- < 24 Hours (SD) 81.28 (159.48) 78.32 (79.34) 0.785
 Mean Average ALT Prior 7 Days (SD) 77.01 (123.52) 78.70 (89.95) 0.781
 Mean Maximum Prior 7 Days ALT (SD) 87.07 (146.59) 92.97 (116.53) 0.415
 Mean Glucose 0- < 24 Hours (SD) 5.59 (2.31) 5.60 (1.83) 0.928
 Mean Glucose 24- < 48 Hours (SD) 5.51 (2.04) 5.64 (2.32) 0.310
 Mean Average Glucose Prior 7 Days (SD) 5.54 (1.64) 5.61 (1.40) 0.341
 Mean Minimum Glucose Prior 7 Days (SD) 5.09 (1.45) 4.93 (1.07) 0.013
 Mean Maximum Glucose Prior 7 Days (SD) 6.17 (3.01) 6.55 (2.79) 0.004
 Mean Sodium 0- < 24 Hours (SD) 138.22 (3.34) 137.54 (3.86) < 0.001
 Mean Sodium 24- < 48 Hours (SD) 139.13 (3.38) 138.97 (3.27) 0.434
 Mean Average Sodium Prior 7 Days (SD) 138.62 (2.96) 138.27 (3.28) 0.006
 Mean Minimum Sodium Prior 7 Days (SD) 137.59 (3.20) 136.65 (3.68) < 0.001
 Mean Maximum Sodium Prior 7 Days (SD) 139.65 (3.46) 139.82 (3.77) 0.255
  1. Abbreviations: SD Standard deviation, ANC Absolute neutrophil count, WBC White blood cell count, BUN Blood urea nitrogen, ALT Alanine aminotransferase
  2. a Units: WBC 109/L, ANC 109/L, BUN mmol/L, creatinine umol/L, albumen g/L, ALT U/L, glucose mmol/L, sodium mmol/L
  3. b Neutropenia defined as ANC < 0.5 × 109/L; renal failure defined as serum creatinine ≥1.5 times upper limit of normal
  4. *** P values calculated using Student’s t-test for continuous variables and chi square test for categorical variables
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