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Table 1 Demographics of the Cohort Stratified by Bloodstream Infection (N = 11,183 cultures)

From: Development and utility assessment of a machine learning bloodstream infection classifier in pediatric patients receiving cancer treatments

  Negative Positive P*
n 10,559 624  
Male Sex 5841 (55.3) 330 (52.9) 0.252
Mean Age (SD) 7.10 (4.82) 7.47 (5.11) 0.062
Down Syndrome 263 (2.5) 26 (4.2) 0.015
ICCC Category    < 0.001
 I. Leukemias, Myeloproliferative Diseases and Myelodysplastic Diseases 5070 (48.0) 403 (64.6)  
 II. Lymphomas and Reticuloendothelial Neoplasms 1325 (12.5) 56 (9.0)  
 III. Central Nervous System Tumors 1223 (11.6) 52 (8.3)  
 IV. Neuroblastoma 899 (8.5) 48 (7.7)  
 V. Retinoblastoma 127 (1.2) 3 (0.5)  
 VI. Renal Tumors 248 (2.3) 2 (0.3)  
 VII. Hepatic Tumors 168 (1.6) 4 (0.6)  
 VIII. Malignant Bone Tumors 528 (5.0) 15 (2.4)  
 IX. Soft-tissue and Other Extraosseous Sarcomas 573 (5.4) 20 (3.2)  
 X. Germ Cell Tumors 146 (1.4) 3 (0.5)  
 XI. Other Malignant Epithelial Neoplasms 103 (1.0) 6 (1.0)  
 XII. Other and unspecified malignant neoplasms 19 (0.2) 1 (0.2)  
 Not cancer undergoing HSCT 130 (1.2) 11 (1.8)  
Ordinal Cancer    0.904
 1 10,446 (98.9) 617 (98.9)  
 2 105 (1.0) 7 (1.1)  
 3 or 4 8 (0.1) 0 (0.0)  
Relapse 1132 (10.7) 134 (21.5) < 0.001
Prior Hematopoietic Stem Cell Transplant
 Allogeneic 739 (7.0) 94 (15.1) < 0.001
 Autologous 914 (8.7) 61 (9.8) 0.373
  1. Abbreviations: SD Standard deviation, ICCC International Classification of Childhood Cancer, HSCT Hematopoietic stem cell transplantation
  2. *P values calculated using Student’s t-test for continuous variables and chi square test for categorical variables
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