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Table 3 Docetaxel Pharmacokinetics (n = 63)

From: A randomized phase II trial evaluating the addition of low dose, short course sunitinib to docetaxel in advanced solid tumours

  Docetaxel-sunitinib Docetaxel alone P value
Tmax (h) 0.95 ± 0.43 0.76 ± 0.33 0.060
Cmax (μg/ml) 4.28 ± 2.07 3.40 ± 1.26 0.044
AUC0-∞ (hours*μg/ml) 6.48 ± 4.43 4.85 ± 1.76 0.053
Cl_pred (L/h) 24.4 ± 13.2 27.4 ± 8.7 0.290
Vss_pred (L) 193.5 ± 248.2 198.5 ± 148.6 0.922
  1. Tmax time to peak serum concentration; Cmax maximum serum concentration; AUC0-∞ area under concentration-time curve; Cl_pred predicted clearance; Vss_pred predicted volume of distribution at steady state
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