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Table 3 Docetaxel Pharmacokinetics (n = 63)

From: A randomized phase II trial evaluating the addition of low dose, short course sunitinib to docetaxel in advanced solid tumours

 

Docetaxel-sunitinib

Docetaxel alone

P value

Tmax (h)

0.95 ± 0.43

0.76 ± 0.33

0.060

Cmax (μg/ml)

4.28 ± 2.07

3.40 ± 1.26

0.044

AUC0-∞ (hours*μg/ml)

6.48 ± 4.43

4.85 ± 1.76

0.053

Cl_pred (L/h)

24.4 ± 13.2

27.4 ± 8.7

0.290

Vss_pred (L)

193.5 ± 248.2

198.5 ± 148.6

0.922

  1. Tmax time to peak serum concentration; Cmax maximum serum concentration; AUC0-∞ area under concentration-time curve; Cl_pred predicted clearance; Vss_pred predicted volume of distribution at steady state
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BMC Cancer

ISSN: 1471-2407

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