Table 2 Adverse Events
Toxicity | All grades | Grade 3 to 5 | ||||
|---|---|---|---|---|---|---|
Docetaxel-sunitinib (N = 33) | Docetaxel alone (N = 35) | P value | Docetaxel-sunitinib (N = 33) | Docetaxel alone (N = 35) | P value | |
All toxicities | 84.8% | 91.4% | 0.400 | 30.3% | 42.9% | 0.285 |
Fatigue | 30.3% | 45.7% | 0.145 | 6.1% | 0% | 0.232 |
Peripheral neuropathy | 27.3% | 31.4% | 0.457 | 0% | 2.9% | 0.515 |
Diarrhoea | 27.3% | 25.7% | 0.551 | 0% | 0% | NA |
Neutropenia | 24.2% | 31.4% | 0.509 | 18.2% | 31.4% | 0.207 |
Nausea | 24.2% | 22.9% | 0.559 | 0% | 0% | NA |
Anorexia | 18.2% | 20.0% | 0.547 | 0% | 0% | NA |
Vomiting | 12.1% | 14.3% | 0.539 | 0% | 0% | NA |
Fever | 12.1% | 11.4% | 0.611 | 6.1% | 11.4% | 0.435 |
Cough | 12.1% | 8.6% | 0.466 | 0% | 0% | NA |
Xerostomia | 12.1% | 2.9% | 0.160 | 0% | 0% | NA |
Dizziness | 12.1% | 0% | 0.050 | 0% | 0% | NA |
Myalgia | 9.1% | 22.9% | 0.112 | 0% | 0% | NA |
Dyspnoea | 6.1% | 17.1% | 0.149 | 0% | 2.9% | 0.515 |
Dyspepsia | 6.1% | 14.3% | 0.239 | 0% | 0% | NA |
Mouth ulcers | 6.1% | 11.4% | 0.365 | 0% | 0% | NA |
Insomnia | 6.1% | 8.6% | 0.528 | 0% | 0% | NA |
Hypersensitivity | 6.1% | 5.7% | 0.670 | 0% | 0% | NA |
Herpes Zoster | 6.1% | 2.9% | 0.478 | 3.0% | 0% | 0.485 |
Sore throat | 6.1% | 2.9% | 0.478 | 0% | 0% | NA |
Dysgeusia | 3.0% | 5.7% | 0.522 | 0% | 0% | NA |
Lower limb oedema | 3.0% | 5.7% | 0.522 | 0% | 2.9% | 0.515 |