nab-PTX plus RAM | PTX plus RAM | P value | ||||
---|---|---|---|---|---|---|
(N = 113) | (N = 138) | |||||
Any grade (%) | >Grade 3 (%) | Any grade (%) | >Grade 3 (%) | Any grade | >Grade 3 | |
All adverse events | 112 (99.1) | 76 (67.3) | 134 (97.1) | 88 (63.8) | 0.254 | 0.563 |
Hematological | ||||||
Neutropenia | 91 (80.5) | 64 (56.6) | 108 (78.3) | 76 (55.1) | 0.659 | 0.804 |
Leukopenia | 85 (75.2) | 34 (30.1) | 107 (77.5) | 48 (34.8) | 0.667 | 0.43 |
Anemia | 105 (92.9) | 8 (7.1) | 112 (81.2) | 19 (13.8) | 0.007 | 0.089 |
Thrombocytopenia | 43 (38.1) | 6 (5.3) | 35 (25.4) | 4 (2.9) | 0.031 | 0.258 |
Non-hematological | ||||||
Sensory neuropathy | 72 (63.7) | 2 (1.8) | 51 (37.0) | 0 (0.0) | 0 | 0.202 |
Fatigue | 42 (37.2) | 1 (0.9) | 33 (23.9) | 0 (0.0) | 0.022 | 0.45 |
Anorexia | 33 (29.2) | 1 (0.9) | 29 (21.0) | 1 (0.7) | 0.134 | 0.699 |
Nausea | 17 (15.0) | 2 (1.8) | 18 (13.0) | 1 (0.7) | 0.649 | 0.425 |
Diarrhea | 7 (6.2) | 0 (0.0) | 14 (10.1) | 0 (0.0) | 0.261 | – |
Stomatitis | 10 (8.8) | 0 (0.0) | 14 (10.1) | 1 (0.7) | 0.728 | 0.55 |
Edema | 33 (29.2) | 0 (0.0) | 32 (23.2) | 0 (0.0) | 0.279 | – |
Proteinuria | 30 (26.5) | 3 (2.7) | 29 (21.0) | 2 (1.4) | 0.304 | 0.406 |
Hypertension | 30 (26.5) | 15 (13.3) | 27 (19.6) | 9 (6.5) | 0.189 | 0.07 |
Febrile neutropenia | 6 (5.1) | 6 (5.1) | 13 (9.4) | 13 (9.4) | 0.221 | 0.221 |
Interstitial pneumonia | 8 (7.1) | 3 (2.7) | 5 (3.6) | 3 (2.2) | 0.219 | 0.56 |
Hypersensitivity reaction | 0 (0.0) | 0 (0.0) | 2 (1.4) | 2 (1.4) | – | – |