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Table 2 Association of lifestyle and KCNB1 related genotype with CRC, CC and RC risk

From: Western influenced lifestyle and Kv2.1 association as predicted biomarkers for Tunisian colorectal cancer

Parameters

Total population (N = 600)

stratification according to tumor site

Colorectal cancer (N = 300)

Colon cancer (N = 190)

Rectal cancer (N = 110)

Bivariate

Multivariable

Bivariate

Multivariable

Bivariate

Multivariable

OR (95%CI)

P

OR (95%CI)

Pa

OR (95%CI)

P

OR (95%CI)

Pa

OR (95%CI)

P

OR (95%CI)

Pa

Age (years)

1.01 (1.00–1.03)

0.098

–

–

1.02 (1.0–1.03)

0.42

–

–

1.00 (0.98–1.02)

0.71

–

–

BMI

0.99 (0.96–1.02)

0.757

–

–

0.99 (0.95–1.02)

0.61

–

–

1.00 (0.96–1.04)

0.91

–

–

Gender (Female)

2.18 (1.56–3.04)

< 0.001

2.20 (1.16–4.2)

0.016

2.16 (1.48–3.14)

< 0.001

2.39 (1.20–4.84)

0.01

2.21 (1.42–3.64)

< 0.001

1.59 (0.67–3.77)

0.28

Vegetable consumptiona

1.28 (0.65–2.38)

0.528

–

–

2.06 (0.90–5.32)

0.10

–

–

0.71 (0.33–1.57)

0.38

–

–

Brine consumptiona

1.19 (0.85–1.66)

0.412

–

–

1.48 (1.00–2.20)

0.04

1.58 (0.82–3.10)

0.16

0.84 (0.53–1.31)

0.44

–

–

Meat consumptiona

0.23 (0.14–0.35)

< 0.001

0.22 (0.14–0.57)

< 0.001

0.24 (0.15–0.39)

< 0.001

0.28 (0.13–0.59)

< 0.001

0.20 (0.12–0.35)

< 0.001

0.20 (0.07–0.35)

< 0.001

Fat consumptiona

7.64 (4.96–12.12)

< 0.001

6.40 (3.45–12.3)

< 0.001

8.89 (5.22–16.1)

< 0.001

6.17 (2.98–13.4)

< 0.001

6.10 (3.38–11.8)

< 0.001

6.26 (2.64–15.9)

< 0.001

Tobacco usersb

2.17 (1.51–3.14)

< 0.001

1.64 (0.81–3.35)

0.146

1.91 (1.26–2.88)

< 0.001

1.44 (0.67–3.13)

0.34

2.70 (1.66–4.32)

< 0.001

2.02 (0.76–5.52)

0.16

Alcohol usersb

2.89 (1.90–4.49)

< 0.001

3.07 (1.48–6.59)

< 0.001

2.91 (1.82–4.68)

< 0.001

2.62 (1.16–6.13)

0.02

2.87 (1.66–4.95)

< 0.001

3.66 (1.35–10.5)

0.01

Physical activity levela

0.03 (0.02–0.05)

< 0.001

0.02 (0.01–0.03)

< 0.001

0.04 (0.02–0.07)

< 0.001

0.028 (0.01–0.05)

< 0.001

0.01 (0.00–0.03)

< 0.001

0.00 (0.00–0.02)

< 0.001

rs3331 (T/T vs. T/C)

1.78 (1.23–2.58)

0.002

1.82 (0.99–3.38)

0.054

1.70 (1.12–2.59)

0.01

1.55 (0.79–3.03)

0.19

1.94 (1.16–3.32)

0.01

2.20 (0.92–5.37)

0.07

rs3331 (T/T vs. C/C)

1.15 (0.72–1.85)

0.549

1.56 (0.73–3.37)

0.248

1.03 (0.59–1.78)

0.89

1.38 (0.58–3.28)

0.45

1.38 (0.71–2.65)

0.33

2.16 (0.73–6.60)

0.16

rs1051295 (A/A vs. A/G)

3.27 (2.14–5.06)

< 0.001

4.65 (2.28–9.76)

< 0.001

3.19 (1.97–5.72)

< 0.001

5.22 (2.38–11.9)

< 0.001

3.34 (1.89–6.52)

< 0.001

3.49 (1.34–9.54)

0.01

rs1051295 (A/A vs. G/G)

1.03 (0.64–1.67)

0.875

1.68 (0.79–3.63)

0.176

0.97 (0.56–1.71)

0.93

1.75 (0.75–4.15)

0.19

1.15 (0.58–2.34)

0.68

1.60 (0.56–4.75)

0.38

rs11468831 (ins/ins vs. ins/del)

0.41 (0.27–0.63)

< 0.001

0.43 (0.21–0.85)

< 0.001

0.38 (0.23–0.60)

< 0.001

0.43 (0.20–0.89)

0.02

0.49 (0.28–0.85)

0.002

0.42 (0.16–1.05)

0.38

rs11468831 (ins/ins vs. del/del)

0.34 (0.23–0.51)

< 0.001

0.27 (0.13–0.51)

< 0.001

0.30 (0.19–0.47)

< 0.001

0.24 (0.11–0.50)

< 0.001

0.44 (0.26–0.74)

0.01

0.65 (0.24–173)

0.06

  1. Value in bold is statistically significant at 5% level of significance
  2. BMI Body Mass Index, OR Odds Ratio, CI Confidence Interval (95%)
  3. P p value comparing all controls vs. Cases (CRC, RC, CC)
  4. Pa p value adjusted for CRC and RC p value was adjusted for gender, physical activity level, tobacco use, alcohol use, meat and fat consumption, for CC p value was adjusted for gender, physical activity level, tobacco use, alcohol use, brine, meat and fat consumption
  5. aThe reference used was the low consumption level
  6. b The reference used was non-users
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BMC Cancer

ISSN: 1471-2407

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