Table 1 Summary of targeted biomarkers and their relative expression levels in breast (MCF7, 4175TR) and ovarian (SKOV3) cancer cell lines. Also listed are the corresponding targeting ligands and nanoparticle compositions
From: Shortwave infrared emitting multicolored nanoprobes for biomarker-specific cancer imaging in vivo
| Â | Biomarker | ||
|---|---|---|---|
CAV1 | CXCR4 | FRα | |
MCF7 expression | + | +++ | ++ |
4175TR expression | +++ | + | – |
SKOV3 expression | +++ | – | +++ |
Targeting ligand | Daidzein | AMD3100 | Folic acid |
Visible / SWIR reporter | Rhodamine / Ho | FITC / Er | Alexa Fluor 647 / Tm |
Targeted nanoparticle | Rh-fHoANC | FITC-fErANC | 647-fTmANC |