Table 1 Patient and transplantation characteristics
All pts. N = 198 | HLAid N = 133 | Haplo N = 65 | p | |
|---|---|---|---|---|
Age, years (median, range) | 32 (18–66) | 32 (18–65) | 31 (18–65) | 0.8 |
Sex M/F | 113/85 | 77/56 | 36/29 | 0.7 |
Number of CT lines (median, range) | 2 (2–12) | 2 (2–9) | 4 (2–12) | < 0.001 |
Previous HDC | 170/198 (86%) | 110/133 (83%) | 60/65 (92%) | 0.007 |
Disease status at transplantation | ||||
CR | 119 (60%) | 82 (62%) | 37 (60%) | |
PR | 79 (40%) | 51 (38%) | 28 (40%) | |
Donors | NA | |||
HLA sibling | / | 57 (43%) | / | |
MUD | / | 76 (57%) | / | |
Haplo | / | / | 65 | |
Stem cell source | ||||
PBSC | 134 (60%) | 114 (83%) | 20 (31%) | < 0.001 |
BM | 63 (31%) | 18 (13%) | 45 (69%) | |
miss | 1 (9%) | 1 (4%) | / | |
ATG prophylaxis GVHD | NA | |||
No | 122 (62%) | 57 (43%) | / | |
Yes | 76 (38%) | 76 (57%) | / | |
Conditioning regimens | ||||
NMAC | 58 (29%) | 2 (2%) | 58 (89%) | < 0.001 |
RIC | 101 (51%) | 92 (69%) | 7 (11%) | |
MAC | 39 (20%) | 39 (29%) | / | |