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Table 3 Multivariate analysis of prognostic factors

From: Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study

Characteristics

P value

HR

95% CI for HR

Age at diagnosis

 40–44 years

 

Reference

 

 45–49 years

0.542

0.932

0.741–1.170

 50–54 years

0.878

1.017

0.821–1.260

 55–59 years

0.024

1.270

1.032–1.562

Race

 White

 

Reference

 

 Black

0.001

1.317

1.127–1.540

 Other a

0.128

1.192

0.951–1.495

Marital status

 Single

 

Reference

 

 Married

0.008

0.819

0.707–0.949

 Other b

0.130

0.871

0.728–1.042

Insurance (yes vs no)

< 0.001

0.587

0.459–0.751

Histology

 Ductal

 

Reference

 

 Lobular

0.744

1.041

0.820–1.321

 Others

0.356

1.105

0.894–1.365

Laterality

 Right

 

Reference

 

 Left

0.506

1.043

0.921–1.182

Bilateral, single primary

0.177

2.21

0.894–1.365

Grade

 I

 

Reference

 

 II

0.309

1.147

0.881–1.492

 III or IV

< 0.001

1.960

1.491–2.577

Tumour subtype

 HR+/HER2-

 

Reference

 

 HR+/HER2+

0.002

0.631

0.474–0.839

 HR−/HER2-

< 0.001

2.808

2.169–3.634

 HR−/HER2+

0.258

0.716

0.401–1.277

Site of metastases

 Lung (yes vs no)

0.020

1.378

1.188–1.598

 Liver (yes vs no)

< 0.001

2.085

1.795–2.422

 Brain (yes vs no)

< 0.001

1.903

1.542–2.248

 Surgery (yes vs no)

< 0.001

0.504

0.431–0.590

 HR+/HER2- * multi-metastases

 

Reference

 

 HR+/HER2+ * multi-metastases

0.045

0.694

0.485–0.992

 HR−/HER2- * multi-metastases

0.717

0.941

0.675–1.310

 HR−/HER2+ * multi-metastases

0.564

0.828

0.437–1.572

Next step

 White*HR+/HER2-

 

Reference

 

 Black*HR+/HER2+

0.366

0.821

0.536–1.258

 Other a*HR+/HER2+

0.652

0.862

0.453–1.641

 Black*HR−/HER2-

0.323

0.817

0.546–1.220

 Other a*HR−/HER2-

0.299

1.508

0.695–3.271

 Black*HR−/HER2+

0.696

0.881

0.466–1.664

 Other a*HR−/HER2+

0.368

0.701

0.323–1.521

  1. Other a (American Indian/AK Native, Asian/Pacific Islander)
  2. Other b (divorced/widowed/separated).