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Table 3 Multivariate analysis of prognostic factors

From: Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study

Characteristics P value HR 95% CI for HR
Age at diagnosis
 40–44 years   Reference  
 45–49 years 0.542 0.932 0.741–1.170
 50–54 years 0.878 1.017 0.821–1.260
 55–59 years 0.024 1.270 1.032–1.562
Race
 White   Reference  
 Black 0.001 1.317 1.127–1.540
 Other a 0.128 1.192 0.951–1.495
Marital status
 Single   Reference  
 Married 0.008 0.819 0.707–0.949
 Other b 0.130 0.871 0.728–1.042
Insurance (yes vs no) < 0.001 0.587 0.459–0.751
Histology
 Ductal   Reference  
 Lobular 0.744 1.041 0.820–1.321
 Others 0.356 1.105 0.894–1.365
Laterality
 Right   Reference  
 Left 0.506 1.043 0.921–1.182
Bilateral, single primary 0.177 2.21 0.894–1.365
Grade
 I   Reference  
 II 0.309 1.147 0.881–1.492
 III or IV < 0.001 1.960 1.491–2.577
Tumour subtype
 HR+/HER2-   Reference  
 HR+/HER2+ 0.002 0.631 0.474–0.839
 HR−/HER2- < 0.001 2.808 2.169–3.634
 HR−/HER2+ 0.258 0.716 0.401–1.277
Site of metastases
 Lung (yes vs no) 0.020 1.378 1.188–1.598
 Liver (yes vs no) < 0.001 2.085 1.795–2.422
 Brain (yes vs no) < 0.001 1.903 1.542–2.248
 Surgery (yes vs no) < 0.001 0.504 0.431–0.590
 HR+/HER2- * multi-metastases   Reference  
 HR+/HER2+ * multi-metastases 0.045 0.694 0.485–0.992
 HR−/HER2- * multi-metastases 0.717 0.941 0.675–1.310
 HR−/HER2+ * multi-metastases 0.564 0.828 0.437–1.572
Next step
 White*HR+/HER2-   Reference  
 Black*HR+/HER2+ 0.366 0.821 0.536–1.258
 Other a*HR+/HER2+ 0.652 0.862 0.453–1.641
 Black*HR−/HER2- 0.323 0.817 0.546–1.220
 Other a*HR−/HER2- 0.299 1.508 0.695–3.271
 Black*HR−/HER2+ 0.696 0.881 0.466–1.664
 Other a*HR−/HER2+ 0.368 0.701 0.323–1.521
  1. Other a (American Indian/AK Native, Asian/Pacific Islander)
  2. Other b (divorced/widowed/separated).
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