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Table 1 Patient Characteristics According to Tumour Subtype

From: Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study

Characteristics HR+/HER2- HR+/HER2+ HR−/HER2- HR−/HER2+ Total P-value
2146(63.41) 672(19.86) 316(9.34) 250(7.39) 3384(100)
Year of diagnosis       0.981
 2012 422(19.66) 133(19.79) 55(17.41) 51(20.40) 661(19.53)  
 2013 441(20.55) 138(20.54) 68(21.52) 52(20.80) 699(20.66)  
 2014 425(19.80) 125(18.60) 65(20.57) 46(18.40) 661(19.53)  
 2015 428(19.94) 143(21.28) 59(18.67) 45(18.00) 675(19.95)  
 2016 430(20.04) 133(19.79) 69(21.84) 56(22.40) 688(20.33)  
Age at diagnosis       0.221
 40–44 years 283(13.19) 107(15.92) 31(9.81) 28(11.20) 449(13.27)  
 45–49 years 465(21.67) 128(19.05) 65(20.57) 50(20.00) 708(20.92)  
 50–54 years 638(29.73) 202(30.06) 110(34.81) 81(32.40) 1031(30.47)  
 55–59 years 760(35.41) 235(34.97) 110(34.81) 91(36.40) 1196(35.34)  
Race       < 0.001
 White 1574(73.35) 481(71.58) 218(68.99) 170(68.00) 2443(72.19)  
 Black 353(16.45) 127(18.90) 81(25.63) 43(17.20) 604(17.85)  
 Other a 211(9.83) 64(9.52) 16(5.06) 33(13.20) 324(9.57)  
 Unknown 8(0.37) 0(0.00) 1(0.32) 4(1.60) 13(0.38)  
Marital status       0.771
 Single 620(28.89) 189(28.13) 89(28.16) 73(29.20) 971(28.69)  
 Married 1049(48.88) 342(50.89) 150(47.47) 113(45.20) 1654(48.88)  
 Other b 377(17.57) 111(16.52) 64(20.25) 47(18.80) 599(17.70)  
 Unknown 100(4.66) 30(4.46) 13(4.11) 17(6.80) 160(4.73)  
Insurance       0.490
 Insured 104(4.85) 42(6.25) 17(5.38) 11(4.40) 174(5.14)  
 Uninsured 2027(94.45) 623(92.71) 297(93.99) 235(94.00) 3182(94.03)  
 Unknown 15(0.70) 7(1.04) 2(0.63) 4(1.60) 28(0.83)  
Grade       < 0.001
 I 247(11.51) 21(3.13) 4(1.27) 2(0.80) 274(8.10)  
 II 1017(47.39) 244(36.31) 64(20.25) 67(26.80) 1392(41.13)  
 III or IV 619(28.84) 334(49.70) 230(72.78) 149(59.60) 1332(39.36)  
 Unknown 263(12.26) 73(10.86) 18(5.70) 32(12.80) 32(12.80)  
Histology       < 0.001
 Ductal 1571(73.21) 559(83.18) 277(87.66) 216(86.40) 2623(77.51)  
 Lobular 353(16.45) 28(4.17) 13(4.11) 6(2.40) 400(11.82)  
 Others 222(10.34) 85(12.65) 26(8.23) 28(11.20) 361(10.67)  
Laterality       0.153
 Right 1054(49.11) 330(49.11) 156(49.37) 102(40.80) 1642(48.52)  
 Left 1070(49.86) 337(50.15) 155(49.05) 146(58.40) 1708(50.47)  
 Bilateral, single primary 5(0.23) 4(0.60) 2(0.63) 1(0.40) 12(0.35)  
 Unknown 17(0.79) 1(0.15) 3(0.95) 1(0.40) 22(0.65)  
Lung metastases       < 0.001
 No 1643(76.56) 452(67.26) 216(68.35) 158(63.20) 2469(72.96)  
 Yes 449(20.92) 205(30.51) 96(30.38) 89(35.60) 839(24.79)  
 Unknown 54(2.52) 15(2.23) 4(1.27) 3(1.20) 76(2.25)  
Liver metastases       < 0.001
 No 1691(78.80) 418(62.20) 208(65.82) 132(52.80) 2449(72.37)  
 Yes 423(19.71) 244(36.31) 101(31.96) 155(46.00) 883(26.09)  
 Unknown 32(1.49) 10(1.49) 7(2.22) 3(1.20) 52(1.54)  
Brain metastases       < 0.001
 No 1992(92.82) 595(88.54) 263(83.23) 214(85.60) 3064(90.54)  
 Yes 107(4.99) 62(9.23) 44(13.92) 31(12.40) 244(7.21)  
 Unknown 47(2.19) 15(2.23) 9(2.85) 5(2.00) 76(2.25)  
Only bone metastases       < 0.001
 No 748(34.86) 360(53.57) 170(53.80) 168(67.20) 1446(42.73)  
 Yes 1326(61.79) 300(44.64) 140(44.30) 80(32.00) 1846(54.55)  
 Unknown 72(3.36) 12(1.79) 6(1.90) 2(0.80) 21(2.72)  
Surgery       0.971
 No 1541(71.81) 489(72.77) 225(71.20) 180(72.00) 2435(71.96)  
 Yes 588(27.40) 179(26.64) 88(27.85) 68(27.20) 923(27.28)  
 Unknown 17(0.79) 4(0.60) 3(0.95) 2(0.80) 26(0.77)  
Breast cancer -specific death       < 0.001
 No 1502(69.99) 504(75.00) 140(44.30) 165(66.00) 2311(68.29)  
 Yes 644(30.01) 168(25.00) 176(55.70) 85(34.00) 1073(31.71)  
Status       < 0.001
 Alive 1350(62.91) 474(70.54) 92(29.11) 153(61.20) 2069(61.14)  
 Dead 796(37.09) 198(29.46) 224(70.89) 97(38.80) 1315(38.86)  
  1. Other a (American Indian/AK Native, Asian/Pacific Islander)
  2. Other b (divorced/widowed/separated)
  3. Patients with unknown data were excluded from the comparative analysis.
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