|
Characteristics
|
HR+/HER2-
|
HR+/HER2+
|
HR−/HER2-
|
HR−/HER2+
|
Total
|
P-value
|
|---|
|
2146(63.41)
|
672(19.86)
|
316(9.34)
|
250(7.39)
|
3384(100)
|
|---|
|
Year of diagnosis
| | | | | |
0.981
|
|
2012
|
422(19.66)
|
133(19.79)
|
55(17.41)
|
51(20.40)
|
661(19.53)
| |
|
2013
|
441(20.55)
|
138(20.54)
|
68(21.52)
|
52(20.80)
|
699(20.66)
| |
|
2014
|
425(19.80)
|
125(18.60)
|
65(20.57)
|
46(18.40)
|
661(19.53)
| |
|
2015
|
428(19.94)
|
143(21.28)
|
59(18.67)
|
45(18.00)
|
675(19.95)
| |
|
2016
|
430(20.04)
|
133(19.79)
|
69(21.84)
|
56(22.40)
|
688(20.33)
| |
|
Age at diagnosis
| | | | | |
0.221
|
|
40–44 years
|
283(13.19)
|
107(15.92)
|
31(9.81)
|
28(11.20)
|
449(13.27)
| |
|
45–49 years
|
465(21.67)
|
128(19.05)
|
65(20.57)
|
50(20.00)
|
708(20.92)
| |
|
50–54 years
|
638(29.73)
|
202(30.06)
|
110(34.81)
|
81(32.40)
|
1031(30.47)
| |
|
55–59 years
|
760(35.41)
|
235(34.97)
|
110(34.81)
|
91(36.40)
|
1196(35.34)
| |
|
Race
| | | | | |
< 0.001
|
|
White
|
1574(73.35)
|
481(71.58)
|
218(68.99)
|
170(68.00)
|
2443(72.19)
| |
|
Black
|
353(16.45)
|
127(18.90)
|
81(25.63)
|
43(17.20)
|
604(17.85)
| |
|
Other a
|
211(9.83)
|
64(9.52)
|
16(5.06)
|
33(13.20)
|
324(9.57)
| |
|
Unknown
|
8(0.37)
|
0(0.00)
|
1(0.32)
|
4(1.60)
|
13(0.38)
| |
|
Marital status
| | | | | |
0.771
|
|
Single
|
620(28.89)
|
189(28.13)
|
89(28.16)
|
73(29.20)
|
971(28.69)
| |
|
Married
|
1049(48.88)
|
342(50.89)
|
150(47.47)
|
113(45.20)
|
1654(48.88)
| |
|
Other b
|
377(17.57)
|
111(16.52)
|
64(20.25)
|
47(18.80)
|
599(17.70)
| |
|
Unknown
|
100(4.66)
|
30(4.46)
|
13(4.11)
|
17(6.80)
|
160(4.73)
| |
|
Insurance
| | | | | |
0.490
|
|
Insured
|
104(4.85)
|
42(6.25)
|
17(5.38)
|
11(4.40)
|
174(5.14)
| |
|
Uninsured
|
2027(94.45)
|
623(92.71)
|
297(93.99)
|
235(94.00)
|
3182(94.03)
| |
|
Unknown
|
15(0.70)
|
7(1.04)
|
2(0.63)
|
4(1.60)
|
28(0.83)
| |
|
Grade
| | | | | |
< 0.001
|
|
I
|
247(11.51)
|
21(3.13)
|
4(1.27)
|
2(0.80)
|
274(8.10)
| |
|
II
|
1017(47.39)
|
244(36.31)
|
64(20.25)
|
67(26.80)
|
1392(41.13)
| |
|
III or IV
|
619(28.84)
|
334(49.70)
|
230(72.78)
|
149(59.60)
|
1332(39.36)
| |
|
Unknown
|
263(12.26)
|
73(10.86)
|
18(5.70)
|
32(12.80)
|
32(12.80)
| |
|
Histology
| | | | | |
< 0.001
|
|
Ductal
|
1571(73.21)
|
559(83.18)
|
277(87.66)
|
216(86.40)
|
2623(77.51)
| |
|
Lobular
|
353(16.45)
|
28(4.17)
|
13(4.11)
|
6(2.40)
|
400(11.82)
| |
|
Others
|
222(10.34)
|
85(12.65)
|
26(8.23)
|
28(11.20)
|
361(10.67)
| |
|
Laterality
| | | | | |
0.153
|
|
Right
|
1054(49.11)
|
330(49.11)
|
156(49.37)
|
102(40.80)
|
1642(48.52)
| |
|
Left
|
1070(49.86)
|
337(50.15)
|
155(49.05)
|
146(58.40)
|
1708(50.47)
| |
|
Bilateral, single primary
|
5(0.23)
|
4(0.60)
|
2(0.63)
|
1(0.40)
|
12(0.35)
| |
|
Unknown
|
17(0.79)
|
1(0.15)
|
3(0.95)
|
1(0.40)
|
22(0.65)
| |
|
Lung metastases
| | | | | |
< 0.001
|
|
No
|
1643(76.56)
|
452(67.26)
|
216(68.35)
|
158(63.20)
|
2469(72.96)
| |
|
Yes
|
449(20.92)
|
205(30.51)
|
96(30.38)
|
89(35.60)
|
839(24.79)
| |
|
Unknown
|
54(2.52)
|
15(2.23)
|
4(1.27)
|
3(1.20)
|
76(2.25)
| |
|
Liver metastases
| | | | | |
< 0.001
|
|
No
|
1691(78.80)
|
418(62.20)
|
208(65.82)
|
132(52.80)
|
2449(72.37)
| |
|
Yes
|
423(19.71)
|
244(36.31)
|
101(31.96)
|
155(46.00)
|
883(26.09)
| |
|
Unknown
|
32(1.49)
|
10(1.49)
|
7(2.22)
|
3(1.20)
|
52(1.54)
| |
|
Brain metastases
| | | | | |
< 0.001
|
|
No
|
1992(92.82)
|
595(88.54)
|
263(83.23)
|
214(85.60)
|
3064(90.54)
| |
|
Yes
|
107(4.99)
|
62(9.23)
|
44(13.92)
|
31(12.40)
|
244(7.21)
| |
|
Unknown
|
47(2.19)
|
15(2.23)
|
9(2.85)
|
5(2.00)
|
76(2.25)
| |
|
Only bone metastases
| | | | | |
< 0.001
|
|
No
|
748(34.86)
|
360(53.57)
|
170(53.80)
|
168(67.20)
|
1446(42.73)
| |
|
Yes
|
1326(61.79)
|
300(44.64)
|
140(44.30)
|
80(32.00)
|
1846(54.55)
| |
|
Unknown
|
72(3.36)
|
12(1.79)
|
6(1.90)
|
2(0.80)
|
21(2.72)
| |
|
Surgery
| | | | | |
0.971
|
|
No
|
1541(71.81)
|
489(72.77)
|
225(71.20)
|
180(72.00)
|
2435(71.96)
| |
|
Yes
|
588(27.40)
|
179(26.64)
|
88(27.85)
|
68(27.20)
|
923(27.28)
| |
|
Unknown
|
17(0.79)
|
4(0.60)
|
3(0.95)
|
2(0.80)
|
26(0.77)
| |
|
Breast cancer -specific death
| | | | | |
< 0.001
|
|
No
|
1502(69.99)
|
504(75.00)
|
140(44.30)
|
165(66.00)
|
2311(68.29)
| |
|
Yes
|
644(30.01)
|
168(25.00)
|
176(55.70)
|
85(34.00)
|
1073(31.71)
| |
|
Status
| | | | | |
< 0.001
|
|
Alive
|
1350(62.91)
|
474(70.54)
|
92(29.11)
|
153(61.20)
|
2069(61.14)
| |
|
Dead
|
796(37.09)
|
198(29.46)
|
224(70.89)
|
97(38.80)
|
1315(38.86)
| |
- Other a (American Indian/AK Native, Asian/Pacific Islander)
- Other b (divorced/widowed/separated)
- Patients with unknown data were excluded from the comparative analysis.
