Table 1 Patient Characteristics According to Tumour Subtype
Characteristics | HR+/HER2- | HR+/HER2+ | HR−/HER2- | HR−/HER2+ | Total | P-value |
|---|---|---|---|---|---|---|
2146(63.41) | 672(19.86) | 316(9.34) | 250(7.39) | 3384(100) | ||
Year of diagnosis | Â | Â | Â | Â | Â | 0.981 |
 2012 | 422(19.66) | 133(19.79) | 55(17.41) | 51(20.40) | 661(19.53) |  |
 2013 | 441(20.55) | 138(20.54) | 68(21.52) | 52(20.80) | 699(20.66) |  |
 2014 | 425(19.80) | 125(18.60) | 65(20.57) | 46(18.40) | 661(19.53) |  |
 2015 | 428(19.94) | 143(21.28) | 59(18.67) | 45(18.00) | 675(19.95) |  |
 2016 | 430(20.04) | 133(19.79) | 69(21.84) | 56(22.40) | 688(20.33) |  |
Age at diagnosis | Â | Â | Â | Â | Â | 0.221 |
 40–44 years | 283(13.19) | 107(15.92) | 31(9.81) | 28(11.20) | 449(13.27) |  |
 45–49 years | 465(21.67) | 128(19.05) | 65(20.57) | 50(20.00) | 708(20.92) |  |
 50–54 years | 638(29.73) | 202(30.06) | 110(34.81) | 81(32.40) | 1031(30.47) |  |
 55–59 years | 760(35.41) | 235(34.97) | 110(34.81) | 91(36.40) | 1196(35.34) |  |
Race |  |  |  |  |  | < 0.001 |
 White | 1574(73.35) | 481(71.58) | 218(68.99) | 170(68.00) | 2443(72.19) |  |
 Black | 353(16.45) | 127(18.90) | 81(25.63) | 43(17.20) | 604(17.85) |  |
 Other a | 211(9.83) | 64(9.52) | 16(5.06) | 33(13.20) | 324(9.57) |  |
 Unknown | 8(0.37) | 0(0.00) | 1(0.32) | 4(1.60) | 13(0.38) |  |
Marital status | Â | Â | Â | Â | Â | 0.771 |
 Single | 620(28.89) | 189(28.13) | 89(28.16) | 73(29.20) | 971(28.69) |  |
 Married | 1049(48.88) | 342(50.89) | 150(47.47) | 113(45.20) | 1654(48.88) |  |
 Other b | 377(17.57) | 111(16.52) | 64(20.25) | 47(18.80) | 599(17.70) |  |
 Unknown | 100(4.66) | 30(4.46) | 13(4.11) | 17(6.80) | 160(4.73) |  |
Insurance | Â | Â | Â | Â | Â | 0.490 |
 Insured | 104(4.85) | 42(6.25) | 17(5.38) | 11(4.40) | 174(5.14) |  |
 Uninsured | 2027(94.45) | 623(92.71) | 297(93.99) | 235(94.00) | 3182(94.03) |  |
 Unknown | 15(0.70) | 7(1.04) | 2(0.63) | 4(1.60) | 28(0.83) |  |
Grade |  |  |  |  |  | < 0.001 |
 I | 247(11.51) | 21(3.13) | 4(1.27) | 2(0.80) | 274(8.10) |  |
 II | 1017(47.39) | 244(36.31) | 64(20.25) | 67(26.80) | 1392(41.13) |  |
 III or IV | 619(28.84) | 334(49.70) | 230(72.78) | 149(59.60) | 1332(39.36) |  |
 Unknown | 263(12.26) | 73(10.86) | 18(5.70) | 32(12.80) | 32(12.80) |  |
Histology |  |  |  |  |  | < 0.001 |
 Ductal | 1571(73.21) | 559(83.18) | 277(87.66) | 216(86.40) | 2623(77.51) |  |
 Lobular | 353(16.45) | 28(4.17) | 13(4.11) | 6(2.40) | 400(11.82) |  |
 Others | 222(10.34) | 85(12.65) | 26(8.23) | 28(11.20) | 361(10.67) |  |
Laterality | Â | Â | Â | Â | Â | 0.153 |
 Right | 1054(49.11) | 330(49.11) | 156(49.37) | 102(40.80) | 1642(48.52) |  |
 Left | 1070(49.86) | 337(50.15) | 155(49.05) | 146(58.40) | 1708(50.47) |  |
 Bilateral, single primary | 5(0.23) | 4(0.60) | 2(0.63) | 1(0.40) | 12(0.35) |  |
 Unknown | 17(0.79) | 1(0.15) | 3(0.95) | 1(0.40) | 22(0.65) |  |
Lung metastases |  |  |  |  |  | < 0.001 |
 No | 1643(76.56) | 452(67.26) | 216(68.35) | 158(63.20) | 2469(72.96) |  |
 Yes | 449(20.92) | 205(30.51) | 96(30.38) | 89(35.60) | 839(24.79) |  |
 Unknown | 54(2.52) | 15(2.23) | 4(1.27) | 3(1.20) | 76(2.25) |  |
Liver metastases |  |  |  |  |  | < 0.001 |
 No | 1691(78.80) | 418(62.20) | 208(65.82) | 132(52.80) | 2449(72.37) |  |
 Yes | 423(19.71) | 244(36.31) | 101(31.96) | 155(46.00) | 883(26.09) |  |
 Unknown | 32(1.49) | 10(1.49) | 7(2.22) | 3(1.20) | 52(1.54) |  |
Brain metastases |  |  |  |  |  | < 0.001 |
 No | 1992(92.82) | 595(88.54) | 263(83.23) | 214(85.60) | 3064(90.54) |  |
 Yes | 107(4.99) | 62(9.23) | 44(13.92) | 31(12.40) | 244(7.21) |  |
 Unknown | 47(2.19) | 15(2.23) | 9(2.85) | 5(2.00) | 76(2.25) |  |
Only bone metastases |  |  |  |  |  | < 0.001 |
 No | 748(34.86) | 360(53.57) | 170(53.80) | 168(67.20) | 1446(42.73) |  |
 Yes | 1326(61.79) | 300(44.64) | 140(44.30) | 80(32.00) | 1846(54.55) |  |
 Unknown | 72(3.36) | 12(1.79) | 6(1.90) | 2(0.80) | 21(2.72) |  |
Surgery | Â | Â | Â | Â | Â | 0.971 |
 No | 1541(71.81) | 489(72.77) | 225(71.20) | 180(72.00) | 2435(71.96) |  |
 Yes | 588(27.40) | 179(26.64) | 88(27.85) | 68(27.20) | 923(27.28) |  |
 Unknown | 17(0.79) | 4(0.60) | 3(0.95) | 2(0.80) | 26(0.77) |  |
Breast cancer -specific death |  |  |  |  |  | < 0.001 |
 No | 1502(69.99) | 504(75.00) | 140(44.30) | 165(66.00) | 2311(68.29) |  |
 Yes | 644(30.01) | 168(25.00) | 176(55.70) | 85(34.00) | 1073(31.71) |  |
Status |  |  |  |  |  | < 0.001 |
 Alive | 1350(62.91) | 474(70.54) | 92(29.11) | 153(61.20) | 2069(61.14) |  |
 Dead | 796(37.09) | 198(29.46) | 224(70.89) | 97(38.80) | 1315(38.86) |  |