|
Subgroups
|
HR (95% CI) a
|
P
|
|---|
|
Fuhrman grade
|
|
Grade I
|
3.23 (1.22–8.53)
|
0.018
|
|
Grade II
|
2.04 (1.51–2.75)
|
< 0.001
|
|
Grade III
|
3.48 (2.75–4.41)
|
< 0.001
|
|
Grade IV
|
1.53 (1.06–2.23)
|
0.024
|
|
Lymph node status
|
|
N0
|
2.94 (2.38–3.64)
|
< 0.001
|
|
N1
|
1.71 (1.30–2.25)
|
< 0.001
|
|
NX
|
3.03 (1.71–5.35)
|
< 0.001
|
|
Sarcomatoid feature
|
|
Yes
|
2.01 (1.25–3.26)
|
0.005
|
|
No
|
2.40 (1.99–2.89)
|
< 0.001
|
|
Unknown
|
3.13 (1.95–5.04)
|
< 0.001
|
|
Bone metastasis
|
|
Yes
|
2.46 (1.87–3.26)
|
< 0.001
|
|
No
|
2.43 (2.00–2.95)
|
< 0.001
|
|
Brain metastasis
|
|
Yes
|
2.16 (1.43–3.25)
|
< 0.001
|
|
No
|
2.46 (2.07–2.94)
|
< 0.001
|
|
Liver metastasis
|
|
Yes
|
3.09 (2.05–4.65)
|
< 0.001
|
|
sNo
|
2.36 (1.99–2.81)
|
< 0.001
|
|
Lung metastasis
|
|
Yes
|
2.50 (2.08–3.01)
|
< 0.001
|
|
No
|
2.22 (1.62–3.06)
|
< 0.001
|
- a: Nephrectomy not recommended vs. nephrectomy recommended and performed
- Abbreviation: HR hazard ratio, 95% CI 95% confidence interval
