Clinical characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
---|---|---|---|---|
Residence | Hangzhou | Hangzhou | Lishui | Shaoxing |
Date of admission | 1-Feb 2020 | 27-Feb 2020 | 9-Mar 2020 | 17-Mar 2020 |
Age (years) | 78 | 56 | 42 | 43 |
Gender | Male | Male | Female | Female |
Cancer type | Esophageal cancer | Hypopharyngeal cancer | Lung cancer | Breast cancer |
Smoking status | Yes | Yes | No | No |
Epidemiological history | Yes (Exposure to relevant environment) | No | No | No |
Other diseases | No | No | Yes (Ovarian cancer and liver cancer) | No |
Treatment history | Chemoradiotherapy 2 months ago | Chemoradiotherapy 2 months ago | Chemotherapy 1 month ago | Chemotherapy 3 weeks ago |
Symptoms | ||||
 Fever | Yes(37.3 °C) | Yes(38.3 °C) | Yes(37.7 °C) | Yes(38.2 °C) |
 Cough | Yes | Yes | Yes | No |
 Fatigue or myalgia | No | Yes | Yes | No |
 Expectoration | Yes | Yes | Yes | No |
 Dyspnea | No | No | No | No |
 Headache | No | Yes | No | No |
 Diarrhea | No | No | No | No |
Laboratory characteristics | ||||
 White blood cell count (× 109 cells per L) | 5 | 7.6 | 12.8 | 5.7 |
 Low leukocyte count (< 9·5 × 109 cells per L) | No | No | No | No |
 Lymphocyte count (× 109 cells per L) | 0.8 | 0.4 | 1.2 | 0.7 |
 Lymphopenia (< 109 cells per L) | Yes | Yes | No | Yes |
CRP (mg/L) | 11.12 | 31.04 | 12.25 | 9.21 |
Elevated CRP (> 10 mg/L) | Yes | Yes | Yes | No |
LDH (U/L) | 141 | 337 | 199 | 296 |
Elevated LDH (> 240 U/L) | No | Yes | No | Yes |
ALT (U/L) | 23 | 17 | 10 | 51 |
Elevated ALT (> 50 U/L) | No | No | No | Yes |
AST (U/L) | 26 | 30 | 25 | 48 |
Elevated AST (> 40 U/L) | No | No | No | Yes |
CT evidence of pneumonia | ||||
 Typical signs of viral infection | Positive | Positive | Positive | Positive |
 1st round of PCR | ||||
 RNA-dependent RNA polymerase (RdRp) | Negative | Negative | Negative | Negative |
 Nucleocapsid (N) gene | Positive | Negative | Negative | Negative |
 2nd round of PCR after 24 h | ||||
 RNA-dependent RNA polymerase (RdRp) | Negative | Negative | Negative | Negative |
 Nucleocapsid (N) gene | Negative | Negative | Negative | Negative |
Follow-up Treatment | ||||
 | Anti-infection therapy | Hormone therapy | Anti-infection therapy and Chemotherapy | Transfer to local hospital |