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Fig. 5 | BMC Cancer

Fig. 5

From: EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

Fig. 5

EP300 expression is correlated with CSC gene expression in the TCGA BC cohort. a, Overlap between TNBC (n = 82) and basal-like BC (n = 81). b, Number of genes positively correlated with EP300 in basal-like BC (n = 509) and TNBC (n = 3036) and overlap of genes (n = 298) (q-value < 0.05). c, Biological functions and pathway associated with the significantly correlated genes (IPA analysis), ranked by p-value (range 1.74 × 10− 4 to 1.34 × 10− 3). Grey arrows indicate overlapping functions between gene lists. d, Affected biological functions and pathways (BRCA/TP53, Notch) associated with EP300 correlated genes that overlap in TNBC and basal BC (n = 298) (cBioPortal). Affected genes are outlined in bold black. Percentages represent the proportion of samples which show alterations in pathway genes (bold – TNBC cases, regular font – basal-like BC). e, Bivariate plots of genes in affected pathways d that are positively correlated with EP300 expression (RSEM – RNA-Seq by Expectation-Maximization)

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