Fig. 5From: EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancerEP300 expression is correlated with CSC gene expression in the TCGA BC cohort. a, Overlap between TNBC (n = 82) and basal-like BC (n = 81). b, Number of genes positively correlated with EP300 in basal-like BC (n = 509) and TNBC (n = 3036) and overlap of genes (n = 298) (q-value < 0.05). c, Biological functions and pathway associated with the significantly correlated genes (IPA analysis), ranked by p-value (range 1.74 × 10− 4 to 1.34 × 10− 3). Grey arrows indicate overlapping functions between gene lists. d, Affected biological functions and pathways (BRCA/TP53, Notch) associated with EP300 correlated genes that overlap in TNBC and basal BC (n = 298) (cBioPortal). Affected genes are outlined in bold black. Percentages represent the proportion of samples which show alterations in pathway genes (bold – TNBC cases, regular font – basal-like BC). e, Bivariate plots of genes in affected pathways d that are positively correlated with EP300 expression (RSEM – RNA-Seq by Expectation-Maximization)Back to article page