Fig. 3

MDA-MB-231^EP300KD does not affect proliferation in vitro but abolishes tumor growth in vivo. a, Growth dynamic of cells in NSG mice (MDA-MB-231^WT, MDA-MB-231^EP300KD clone 1 and 2, n = 5 per cell line), p-values (1) - WT vs. EP300 KD clones, (2) – scramble vs. EP300 KD clones. b, Representative images of explanted tumors post xenograft culture. c, Growth dynamics (4 days) in vitro of MDA-MB-231^WT (dotted line) and MDA-MB-231^EP300KD (n = 3 per cell line). (***p < 0.001, ****p < 0.0001). d, Growth curve in vitro of MDA-MB-231^EP300KD (dotted line) post xenograft (n = 3 per cell line). e, Growth dynamic of MDA-MB-231 xenograft in female NSG mice (MDA-MB-231^WT, EP300 KD clone 1, mixed xenograft (WT and EP300 KD clone 1 mixed 1:1), n = 5 mice per cell line. f, FACS analysis of cell composition after mixed xenograft experiment (WT – mCherry, EP300 KD – GFP)