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Fig. 7 | BMC Cancer

Fig. 7

From: A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma

Fig. 7

BRF2 alterations alter overall patient survival in an age-dependent manner. Using the cBioPortal [26], we queried a subset of the Invasive Breast Cancer Data Set (TCGA, Firehose Legacy) [28, 34, 35] for BRF2 alterations, restricting our analysis to complete patient data sets which included mutations, CNA, and mRNA microarray expression data (960 patients). Overall survival Kaplan-Meier estimate was determined comparing patients overall survival status, by month, in patients with alterations (red line) to those without alterations (blue line) in BRF2 analyzed by age of diagnosis: (a) 35 < X < 40, (b) 40 < X < 45, (c) 45 < X < 50, and (d) 50 < X < 55. Logrank p-value for each overall survival Kaplan-Meier estimated is noted. The Breast Invasive Carcinoma data set analyzed is available at the cBioPortal (www.cbioportal.org). Queries of the cBioPortal were performed in September 2019, October 2019, November 2019, January 2020, February 2020, and March 2020

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