Fig. 2From: Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief reviewZA inhibits mevalonate pathway. ZA inhibits farnesyl pyrophosphate synthase (FPPS) and geranylgeranyl pyrophosphate synthase (GGPPS), prevents the biosynthesis of FPP and GGPP that are required for the post-translational prenylation of small GTP-binding proteins such as Rab, Rho and Rac, leading to apoptosis of the osteoclastsBack to article page