Groups | Radiation | CKD-516 | Short-term (1 cycle) (n = 6) | Long-term (3 cycles) (n = 10) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
% TGI | % TGD (2000 mm3) | % TGI | % TGD (2000 mm3) | |||||||
24 h | 72 h | 24 h | 72 h | 24 h | 72 h | 24 h | 72 h | |||
Vehicle | – | – | – | – | – | – | – | – | – | – |
IR | 2 Gy | – | – | – | – | – | 51.9** | 56.2** | 15.1** | 14.9** |
4 Gy | – | 27.8** | 55.5* | 12.6** | 27.0* | – | – | – | – | |
CKD-516 | – | 3 mg/kg | 1.5 | 49.2 | 0.5 | 21.0 | 9.6 | 10.5 | 1.5 | 1.4 |
CKD-516 + IR (d1) | 2 Gy | 3 mg/kg | – | – | – | – | 60.9** | 71.2** | 21.7** | 28.8** |
4 Gy | 3 mg/kg | 28.6 | 58.5* | 13.2 | 30.6* |  |  |  |  | |
CKD-516 + IR (d1, 5) | 4 Gy | 3 mg/kg | 27.9* | 32.2* | 12.7* | 10.3* |  |  |  |  |