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Table 1 Tumor growth inhibition and tumor growth delay by CKD-516 combined with IR

From: Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma

Groups

Radiation

CKD-516

Short-term (1 cycle) (n = 6)

Long-term (3 cycles) (n = 10)

% TGI

% TGD (2000 mm3)

% TGI

% TGD (2000 mm3)

24 h

72 h

24 h

72 h

24 h

72 h

24 h

72 h

Vehicle

–

–

–

–

–

–

–

–

–

–

IR

2 Gy

–

–

–

–

–

51.9**

56.2**

15.1**

14.9**

4 Gy

–

27.8**

55.5*

12.6**

27.0*

–

–

–

–

CKD-516

–

3 mg/kg

1.5

49.2

0.5

21.0

9.6

10.5

1.5

1.4

CKD-516

+ IR (d1)

2 Gy

3 mg/kg

–

–

–

–

60.9**

71.2**

21.7**

28.8**

4 Gy

3 mg/kg

28.6

58.5*

13.2

30.6*

    

CKD-516

+ IR (d1, 5)

4 Gy

3 mg/kg

27.9*

32.2*

12.7*

10.3*

    
  1. Notes: IR Radiation, TGI Tumor growth inhibition, TGD Tumor growth delay. *denotes p < 0.05, **denotes p < 0.01. % TGI = 100 - (T/C × 100), where T = mean tumor volume of treatment group and C = mean tumor volume of vehicle group. % TGD = (T - C)/C × 100, where T = median time to endpoint of treatment group and C = median time to endpoint of vehicle group