Table 1 Relationships between clinicopathological characteristics and CONUT score, PNI, and mGPS
From: Nutritional and inflammatory measures predict survival of patients with stage IV colorectal cancer
| Â | Â | CONUT score | Â | PNI | Â | mGPS | Â | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All cases | Low (0/1) | Intermediate (2/3) | High (≥4) | P value | Low (< 48.0) | High (≥48.0) | P value | 0 | 1 | 2 | P value | ||||||||||
Cases | 996 | 614 (61%) | 276 (28%) | 106 (11%) | Â | 443 (44%) | 553 (56%) | Â | 633 (64%) | 234 (23%) | 129 (13%) | Â | |||||||||
Age (years) | |||||||||||||||||||||
  < 65 | 625 (63%) | 399 (65%) | 170 (62%) | 56 (53%) | 0.052 | 249 (56%) | 376 (68%) | < 0.001 | 392 (62%) | 160 (68%) | 73 (57%) | 0.066 | |||||||||
  ≥ 65 | 371 (37%) | 215 (35%) | 106 (38%) | 50 (47%) |  | 194 (44%) | 177 (32%) |  | 241 (38%) | 74 (32%) | 56 (43%) |  | |||||||||
Gender | |||||||||||||||||||||
 Male | 573 (58%) | 340 (55%) | 167 (61%) | 66 (62%) | 0.208 | 239 (54%) | 334 (60%) | 0.041 | 277 (44%) | 93 (40%) | 53 (41%) | 0.537 | |||||||||
 Female | 423 (42%) | 274 (45%) | 109 (39%) | 40 (38%) |  | 204 (46%) | 219 (40%) |  | 356 (56%) | 141 (60%) | 76 (59%) |  | |||||||||
BMI | |||||||||||||||||||||
  < 20 kg/m2 | 264 (27%) | 131 (21%) | 89 (32%) | 44 (42%) | < 0.001 | 152 (34%) | 112 (20%) | < 0.001 | 162 (26%) | 51 (22%) | 51 (40%) | < 0.001 | |||||||||
  ≥ 20 kg/m2 | 732 (73%) | 483 (79%) | 187 (68%) | 62 (58%) |  | 291 (66%) | 441 (80%) |  | 471 (74%) | 183 (78%) | 78 (60%) |  | |||||||||
ECOG performance status | |||||||||||||||||||||
 PS0, PS1 | 961 (96%) | 600 (98%) | 267 (97%) | 94 (89%) | < 0.001 | 418 (94%) | 543 (98%) | 0.001 | 623 (98%) | 223 (95%) | 115 (89%) | < 0.001 | |||||||||
 PS2, PS3, PS4 | 35 (4%) | 14 (2%) | 9 (3%) | 12 (11%) |  | 25 (6%) | 10 (2%) |  | 10 (2%) | 11 (5%) | 14 (11%) |  | |||||||||
Location of primary tumor | |||||||||||||||||||||
 Right-sided | 293 (29%) | 158 (26%) | 95 (34%) | 40 (38%) | 0.004 | 163 (37%) | 130 (24%) | < 0.001 | 169 (27%) | 77 (33%) | 47 (36%) | 0.035 | |||||||||
 Left-sided | 703 (71%) | 456 (74%) | 181 (66%) | 66 (62%) |  | 280 (63%) | 423 (76%) |  | 464 (73%) | 157 (67%) | 82 (64%) |  | |||||||||
CEA | |||||||||||||||||||||
  < 30 ng/ml | 524 (53%) | 351 (57%) | 133 (48%) | 40 (38%) | < 0.001 | 186 (42%) | 338 (61%) | < 0.001 | 404 (64%) | 86 (37%) | 34 (26%) | < 0.001 | |||||||||
  ≥ 30 ng/ml | 472 (47%) | 263 (43%) | 143 (52%) | 66 (62%) |  | 257 (58%) | 215 (39%) |  | 229 (36%) | 148 (63%) | 95 (74%) |  | |||||||||
Histological type | |||||||||||||||||||||
 Differentiated | 897 (90%) | 553 (90%) | 249 (90%) | 95 (90%) | 0.985 | 396 (89%) | 501 (91%) | 0.527 | 576 (91%) | 205 (88%) | 116 (90%) | 0.334 | |||||||||
 Others | 99 (10%) | 61 (10%) | 27 (10%) | 11 (10%) |  | 47 (11%) | 52 (9%) |  | 57 (9%) | 29 (12%) | 13 (10%) |  | |||||||||
M category | |||||||||||||||||||||
 M1a | 553 (56%) | 355 (58%) | 145 (53%) | 53 (50%) | 0.268 | 230 (52%) | 323 (58%) | 0.080 | 388 (61%) | 106 (45%) | 59 (46%) | < 0.001 | |||||||||
 M1b | 227 (23%) | 132 (21%) | 64 (23%) | 31 (29%) |  | 114 (26%) | 113 (20%) |  | 119 (19%) | 64 (27%) | 44 (34%) |  | |||||||||
 M1c | 216 (22%) | 127 (21%) | 67 (24%) | 22 (21%) |  | 99 (22%) | 117 (21%) |  | 126 (20%) | 64 (27%) | 26 (20%) |  | |||||||||
Surgical treatment | |||||||||||||||||||||
 Curative resection | 302 (30%) | 208 (34%) | 74 (27%) | 20 (19%) | < 0.001 | 101 (23%) | 201 (36%) | < 0.001 | 257 (40%) | 33 (14%) | 12 (9%) | < 0.001 | |||||||||
 Palliative resection of primary tumor | 303 (30%) | 694 (70%) | 208 (34%) | 406 (66%) | 74 (27%) | 202 (73%) | 21 (20%) | 86 (81%) |  | 120 (27%) | 342 (77%) | 183 (33%) | 352 (64%) |  | 207 (33%) | 376 (60%) | 68 (29%) | 201 (86%) | 28 (22%) | 117 (91%) |  |
 No resection | 391 (40%) | 198 (32%) | 128 (46%) | 65 (61%) | 222 (50%) | 169 (31%) | 169 (27%) | 133 (57%) | 89 (69%) | ||||||||||||
Albumin (g/dl) | 4.0 (3.7–4.3) | 4.1 (3.9–4.4) | 3.9 (3.5–4.2) | 3.1 (2.8–3.4) | < 0001 | 3.7 (3.3–3.9) | 4.3 (4.1–4.4) | < 0.001 | 4.2 (4.0–4.4) | 3.8 (3.7–4.0) | 3.2 (2.9–3.3) | < 0.001 | |||||||||
CRP (mg/dl) | 0.5 (0.1–2.0) | 0.3 (0.1–1.1) | 0.8 (0.2–2.7) | 4.3 (1.2–8.2) | < 0001 | 1.5 (0.4–4.6) | 0.2 (0.1–0.7) | < 0.001 | 0.2 (0.1–0.4) | 2.3 (1.4–4.1) | 5.8 (2.6–8.4) | < 0.001 | |||||||||
Total cholesterol (mg/dl) | 203 (173–240) | 210 (186–243) | 193 (165–235) | 162 (136–221) | < 0001 | 196 (164–239) | 208 (182–240) | < 0.001 | 203 (176–233) | 201 (172–257) | 205 (157–256) | 0.574 | |||||||||
Lymphocytes (mm3) | 1600 (1200–2000) | 1800 (1520–2200) | 1125 (1000–1500) | 1105 (900–1508) | < 0001 | 1300 (1070–1600) | 1870 (1500–2270) | < 0.001 | 1640 (1300–2000) | 1600 (1200–2100) | 1320 (1070–1700) | < 0.001 | |||||||||