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Table 1 Relationships between clinicopathological characteristics and CONUT score, PNI, and mGPS

From: Nutritional and inflammatory measures predict survival of patients with stage IV colorectal cancer

   CONUT score   PNI   mGPS  
All cases Low (0/1) Intermediate (2/3) High (≥4) P value Low (< 48.0) High (≥48.0) P value 0 1 2 P value
Cases 996 614 (61%) 276 (28%) 106 (11%)   443 (44%) 553 (56%)   633 (64%) 234 (23%) 129 (13%)  
Age (years)
  < 65 625 (63%) 399 (65%) 170 (62%) 56 (53%) 0.052 249 (56%) 376 (68%) < 0.001 392 (62%) 160 (68%) 73 (57%) 0.066
  ≥ 65 371 (37%) 215 (35%) 106 (38%) 50 (47%)   194 (44%) 177 (32%)   241 (38%) 74 (32%) 56 (43%)  
Gender
 Male 573 (58%) 340 (55%) 167 (61%) 66 (62%) 0.208 239 (54%) 334 (60%) 0.041 277 (44%) 93 (40%) 53 (41%) 0.537
 Female 423 (42%) 274 (45%) 109 (39%) 40 (38%)   204 (46%) 219 (40%)   356 (56%) 141 (60%) 76 (59%)  
BMI
  < 20 kg/m2 264 (27%) 131 (21%) 89 (32%) 44 (42%) < 0.001 152 (34%) 112 (20%) < 0.001 162 (26%) 51 (22%) 51 (40%) < 0.001
  ≥ 20 kg/m2 732 (73%) 483 (79%) 187 (68%) 62 (58%)   291 (66%) 441 (80%)   471 (74%) 183 (78%) 78 (60%)  
ECOG performance status
 PS0, PS1 961 (96%) 600 (98%) 267 (97%) 94 (89%) < 0.001 418 (94%) 543 (98%) 0.001 623 (98%) 223 (95%) 115 (89%) < 0.001
 PS2, PS3, PS4 35 (4%) 14 (2%) 9 (3%) 12 (11%)   25 (6%) 10 (2%)   10 (2%) 11 (5%) 14 (11%)  
Location of primary tumor
 Right-sided 293 (29%) 158 (26%) 95 (34%) 40 (38%) 0.004 163 (37%) 130 (24%) < 0.001 169 (27%) 77 (33%) 47 (36%) 0.035
 Left-sided 703 (71%) 456 (74%) 181 (66%) 66 (62%)   280 (63%) 423 (76%)   464 (73%) 157 (67%) 82 (64%)  
CEA
  < 30 ng/ml 524 (53%) 351 (57%) 133 (48%) 40 (38%) < 0.001 186 (42%) 338 (61%) < 0.001 404 (64%) 86 (37%) 34 (26%) < 0.001
  ≥ 30 ng/ml 472 (47%) 263 (43%) 143 (52%) 66 (62%)   257 (58%) 215 (39%)   229 (36%) 148 (63%) 95 (74%)  
Histological type
 Differentiated 897 (90%) 553 (90%) 249 (90%) 95 (90%) 0.985 396 (89%) 501 (91%) 0.527 576 (91%) 205 (88%) 116 (90%) 0.334
 Others 99 (10%) 61 (10%) 27 (10%) 11 (10%)   47 (11%) 52 (9%)   57 (9%) 29 (12%) 13 (10%)  
M category
 M1a 553 (56%) 355 (58%) 145 (53%) 53 (50%) 0.268 230 (52%) 323 (58%) 0.080 388 (61%) 106 (45%) 59 (46%) < 0.001
 M1b 227 (23%) 132 (21%) 64 (23%) 31 (29%)   114 (26%) 113 (20%)   119 (19%) 64 (27%) 44 (34%)  
 M1c 216 (22%) 127 (21%) 67 (24%) 22 (21%)   99 (22%) 117 (21%)   126 (20%) 64 (27%) 26 (20%)  
Surgical treatment
 Curative resection 302 (30%) 208 (34%) 74 (27%) 20 (19%) < 0.001 101 (23%) 201 (36%) < 0.001 257 (40%) 33 (14%) 12 (9%) < 0.001
 Palliative resection of primary tumor 303 (30%) 694 (70%) 208 (34%) 406 (66%) 74 (27%) 202 (73%) 21 (20%) 86 (81%)   120 (27%) 342 (77%) 183 (33%) 352 (64%)   207 (33%) 376 (60%) 68 (29%) 201 (86%) 28 (22%) 117 (91%)  
 No resection 391 (40%) 198 (32%) 128 (46%) 65 (61%) 222 (50%) 169 (31%) 169 (27%) 133 (57%) 89 (69%)
Albumin (g/dl) 4.0 (3.7–4.3) 4.1 (3.9–4.4) 3.9 (3.5–4.2) 3.1 (2.8–3.4) < 0001 3.7 (3.3–3.9) 4.3 (4.1–4.4) < 0.001 4.2 (4.0–4.4) 3.8 (3.7–4.0) 3.2 (2.9–3.3) < 0.001
CRP (mg/dl) 0.5 (0.1–2.0) 0.3 (0.1–1.1) 0.8 (0.2–2.7) 4.3 (1.2–8.2) < 0001 1.5 (0.4–4.6) 0.2 (0.1–0.7) < 0.001 0.2 (0.1–0.4) 2.3 (1.4–4.1) 5.8 (2.6–8.4) < 0.001
Total cholesterol (mg/dl) 203 (173–240) 210 (186–243) 193 (165–235) 162 (136–221) < 0001 196 (164–239) 208 (182–240) < 0.001 203 (176–233) 201 (172–257) 205 (157–256) 0.574
Lymphocytes (mm3) 1600 (1200–2000) 1800 (1520–2200) 1125 (1000–1500) 1105 (900–1508) < 0001 1300 (1070–1600) 1870 (1500–2270) < 0.001 1640 (1300–2000) 1600 (1200–2100) 1320 (1070–1700) < 0.001
  1. CONUT Controlling nutritional status, PNI Prognostic nutritional index, mGPS Modified Glasgow prognostic score, BMI Body mass index, ECOG PS Eastern Cooperative Oncology Group performance status, CEA Carcinoembryonic antigenNumerical data are expressed as median (25–75% interquartile range)
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