Fig. 5

ANP32E activates β-catenin to promote the proliferation and migration of pancreatic cancer cells. a and b Western blot results of β-catenin and cyclin D1 in Ctrl and ANP32E over-expressed, shCtrl and shANP32E MIA (a) and PANC1 (b) cells. c Western blot results of β-catenin in siCtrl and siCTNNB PANC1 cells with highly expressed ANP32E. d siCtrl and siCTNNB PANC1 cells were subjected to CCK8 analysis of cell proliferation. *p < 0.05. **p < 0.01. e siCtrl and siCTNNB PANC1 cells were subjected to Transwell analysis of migration. **p < 0.01. Results are mean ± SEM (n = 3). Full-length gels are presented in Supplementary Figure 2. Scale bar, 200 um